Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1975; 34(01): 020-030DOI: 10.1055/s-0038-1651442 International Committee Business Schattauer GmbH A Standard for Human Plasmin[*] Authors Author Affiliations T. B. L Kirkwood 1 National Institute for Biological Standards and Control, Hampstead, London NW3 6RB P. J Campbell 1 National Institute for Biological Standards and Control, Hampstead, London NW3 6RB P. J Gaffney 1 National Institute for Biological Standards and Control, Hampstead, London NW3 6RB Recommend Article Abstract Buy Article(opens in new window) Summary An international collaborative study involving ten laboratories was undertaken to assess the suitability of a preparation of human plasmin in 50% glycerol to serve as a single standard for the bioassay of plasmin activity. The study included examination of the stability of the proposed standard and comparisons between assay methods. The results suggest that the human plasmin preparation coded 72/379 is suitable to serve as a standard. It is sufficiently stable to define the unit of plasmin activity for several years at or below 4° C and for short periods at about 20° C. The preparation has been assigned a potency of 8 units per ml. The International Committee on Thrombosis and Haemostasis (Basle, 1974) has recommended the use of this material as a standard. Full Text References References 1 Alkjaersig N, Fletcher A. P, and Sherry S. 1959; The mechanism of clot dissolution by plasmin. Journal of Clinical Investigation 38: 1086. 2 Bishop R, Ekert H, Gilchrist G, Schanbrom E, and Fekete L. 1970; The preparation and evaluation of a standardized fibrin plate for the assessment of fibrinolytic activity. Thrombosis et Diathesis Haemorrhagica 23: 202. 3 Bliss C. I. 1952. The statistics of bioassay, with special refer enee to the vitamins. Academic Press Inc. 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