Summary
Suloctidil, a compound with antithrombotic properties in animal models, causes depletion
of human platelet serotonin stores during 1–5 hr incubation with platelet-rich plasma
in vitro. This effect is not attended by leakage of cytoplasmic nucleotides or by
alterations in cyclic AMP metabolism, malondialdehyde production or energy balance.
5HT uptake was also inhibited but uptake of adenine was not. 5HT released by suloctidil
appeared in the supernatant as oxidation products, though the amine also accumulated
when re-uptake was blocked by imipramine.
