Dialysis and Renal Transplant in a Hemophiliac

Edward D Gomperts; Mohammed H Malekzadeh; Richard N Fine

doi:10.1055/s-0038-1653433

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1981; 46(03): 626-628
DOI: 10.1055/s-0038-1653433

Original Article

Schattauer GmbH Stuttgart

Dialysis and Renal Transplant in a Hemophiliac

Authors

Edward D Gomperts

The Divisions of Dialysis, Transplant and Hematology, Oncology, Department of Pediatrics, Childrens Hospital of Los Angeles and University of Southern California, Los Angeles, California, U.S.A
Mohammed H Malekzadeh

The Divisions of Dialysis, Transplant and Hematology, Oncology, Department of Pediatrics, Childrens Hospital of Los Angeles and University of Southern California, Los Angeles, California, U.S.A
Richard N Fine

The Divisions of Dialysis, Transplant and Hematology, Oncology, Department of Pediatrics, Childrens Hospital of Los Angeles and University of Southern California, Los Angeles, California, U.S.A

Abstract

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Summary

Hemodialysis was initiated in a mild-moderate hemophiliac at 15 years of age. Hematuria had been a frequent and persisting feature from the age of five years without documented cause. Anemia and proteinuria was first detected at 13 years. A cadaver donor renal transplant was carried out after three months of hemodialysis. Massive intravesical bleeding complicated the immediate post-transplantation period. The allograft rejected after three months and the patient was maintained for eight years on home hemodialysis. A second cadaver donor allograft was carried out at 23 years of age. Again, massive intravesical hemorrhage was a problem post-transplant. The allograft is currently functioning 27 months post-transplant. Factor VIII_c activities have fluctuated between 5% and 40% in the absence of factor infusions.

Keywords

Transplant - Hemophilia

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Referenzen

References
1 Koene RA P, Gerlag PG G, Jansen JL F, Moulijn AC, Skotnicki SH, Debruyne FJ M, Kunst VA J M, Geerdink P, Wijdeveld PG A B. Successful haemodialysis and renal transplantation in a patient with haemophilia A. Proc Eur Dial Transplant Assoc 1977; 14: 401-406
2 Mannucci PM, Ruggeri AM, Pareti FI. 1-deamino-8-d-arginine vasopressin: A new pharmacological approach to the management of hemophilia and von Willebrands’ diseases. Lancet 1977; 1: 869-872
3 Sarji KE, Levine JH, Nair RM G, Sagel J, Colwell JA. Relation between growth hormone levels and von Willebrand factor activity. J Clin Endocrinol Metab 1977; 45: 853-856
4 Webster WP, Aubroski CF, Hutchin P, Reddick RL, Mandel SR, Perrick GD. Plasma factor VIII synthesis and control as revealed by canine organ transplantation. Am J Physiol 1971; 22: 1147-1154