Influence of Factor V and Factor Va on APC-Induced Cleavage of Human Factor VIII

Thromb Haemost 1995; 73(04): 730-731
DOI: 10.1055/s-0038-1653853

Letters to the Editor

Schattauer GmbH Stuttgart

Authors

Katalin Váradi

¹Immuno AG, Vienna, Austria
Jan Rosing

²Dept. of Biochemistry, University of Limburg, Maastricht, The Netherlands
Guido Tans

²Dept. of Biochemistry, University of Limburg, Maastricht, The Netherlands
Hans Peter Schwarz

¹Immuno AG, Vienna, Austria

References
1 Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993; 90: 1004-1008
2 Dahlbäck B, Hildebrand A. Inherited resistance to activated protein C is corrected by anticoagulant cofactor activity found to be a property of factor V. Proc Natl Acad Sci USA 1994; 91: 1396-1400
3 Shen L, Dahlbäck B. Factor V and protein S as synergistic cofactors to activated protein C in degradation of factor VIIIa. J Biol Chem 1994; 269: 18735-18738
4 Fay PJ, Smudzin TM, Walker FJ. Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. J Biol Chem 1991; 20139-20145
5 Tans G, Rosing J, Thomassen MC L G D, Heeb MJ, Zwaal RF A, Griffin JH. Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles. Blood 1991; 77: 2641-2648
6 Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-685
7 Walker FJ, Chavin SI, Fay PJ. Inactivation of factor VIII by activated protein C and protein S. Arch Biochem Biophys 1987; 252: 322-328