Fibrinolysis: Mathematical and Experimental Studies^[*]

Summary

In the present paper we discuss a mathematical model of fibrinolysis, encompassing the major chemical reactions associated with this process, and show that it is in good agreement with the results of extensive experimental studies. We anticipate that such mathematical simulation, possibly combined with automation of auxiliary experimental measurements, may serve as a basis for faster and simpler clinical assays.

• References

• 1 Liniger W, Ruegsegger P. A mathematical model of fibrinolysis. To be published in Mathematical Biosciences.
• 2 Ruegsegger P, Liniger W, LaDue J. S. The fibrinolytic reaction. Mathematical-experimental studies on blood clot dissolution with reference to clinical thrombolysis and auto-regulation. (Inpreparation.)
• 3 Pechet L. New Engl. J. Med 273: 966 1024 1965;
• 4 Sherry S, Fletcher A. P, Alkjaersig N. Physiol. Rev 39: 343 1959;
• 5 Cohen S. L, Warren R. New Engl. J. Med 264: 79 128 1961;
• 6 Frost A, Pearson R. Kinetics and Mechanism. Sec. ed.. 8 John Wiley and Sons, Inc.; New York: 1961
• 7 Kline D. L, Fishman J. B. J. biol. Chem 236: 10 2807 1961;
• 8 Norman P. S. Amer. J. Card., Symp. on Fibrinolysis 6: 2 390 1960;
• 9 Macfarlane R. G. Brit. med. Bull 20: 3 173 1964;
• 10 Norman P. S. Fed. Proc. (In press.)
• 11 Norman P. S. J. exp. Med 106: 53 1958;
• 12 DeRenzo E. C, Boggiano E, Hummel B. C. W. Fed. Proc 24: 260 1965;
• 13 Norman P. S. Proc. Soc. exp. Biol. (N. Y.) 96: 709 1957;