Prothrombin Utilization Following Addition of Platelet Cofactor I Concentrates to Hemophilic Plasma

J Frederic Johnson; Eberhard F. Mammen; Walter H. Seegers

doi:10.1055/s-0038-1654414

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1959; 3(04): 588-592
DOI: 10.1055/s-0038-1654414

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Prothrombin Utilization Following Addition of Platelet Cofactor I Concentrates to Hemophilic Plasma

Autoren

J Frederic Johnson

¹Department of Physiology and Pharmacology, Wayne State University, College of Medicine, Detroit, Michigan, USA.
Eberhard F. Mammen

¹Department of Physiology and Pharmacology, Wayne State University, College of Medicine, Detroit, Michigan, USA.
Walter H. Seegers^*)

¹Department of Physiology and Pharmacology, Wayne State University, College of Medicine, Detroit, Michigan, USA.

Abstract

Summary

Prothrombin is utilized in hemophilia B blood when a platelet cofactor I concentrate is added. It is not well utilized when the same preparation is added to hemophilia B plasma, hemophilia A plasma, or hemophilia A blood. Platelet factor 3 concentrates did not promote prothrombin utilization. Mixtures of platelet cofactor I and platelet factor 3 (threone) give prothrombin utilization under all conditions tested in hemophilia A and B.

Volltext

Referenzen

References
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