Thrombosis and Haemostasis, Inhaltsverzeichnis Thromb Haemost 1961; 05(03): 396-401DOI: 10.1055/s-0038-1654934 Originalarbeiten – Original Article – Travaux Originaux Schattauer GmbH Preliminary Studies on the N-Terminal Amino Acids of Human Plasminogen[*] Authors Institutsangaben Sidney Shulman ** 1 Department of Biophysics, University of Buffalo School of Medicine, Buffalo, N.Y., USA Ubaldo Rifé 1 Department of Biophysics, University of Buffalo School of Medicine, Buffalo, N.Y., USA Artikel empfehlen Abstract Artikel einzeln kaufen(opens in new window) Summary Human plasminogen has been analyzed for N-terminal amino acids. It was found to have one residue each of lysine and serine per molecule, with the possibility that threonine and glutamic acid may also serve in this role. On conversion to SK-plasmin, serine is lost as a terminal group and leucine appears as a new terminal unit. Volltext Referenzen References 1 Shulman S, Alkjaersig N, Sherry S. Physicochemical studies on human plasminogen (profibrinolysin) and plasmin (fibrinolysin). J. biol. Chem. 233: 91 1958; 2 Sgouris J. T, Inman J. K, McCall K. B. Starchgel and moving boundary electrophoresis of highly purified profibrinolysin. Biochem. Biophys. Res. Communs. 02: 40 1960; 3 Kline D. L. The purification and crystallization of plasminogen (profibrinolysin). J. biol. Chem. 204: 949 1953; 4 Remmert L. F, Cohen P. P. Partial purification and properties of a proteolytic enzyme of human serum. J. biol. Chem. 181: 431 1949; 5 Shulman S. Purification and identification of components of human plasminogen. Biochim. biophys. Acta. 46: 6 1961; 6 Fraenkel-Conrat Harris J. I, Levy A. L. Recent developments in techniques for terminal and sequence studies in peptides and proteins. Methods of Biochemical Analysis 02: 359 1955; 7 Biserte G, Osteux R. La chromatographie de partage sur papier des dinitro-phenyl amino acides. Bull. Soc. chim. biol. 33: 50 1951; 8 Levy A. L, Geschwind I. I, Li C. H. Corticotropins (ACTH). II. amino acid composition of a-corticotropin. J. biol. Chem. 213: 187 1953; 9 McFadden M. L, Smith E. L. Free amino groups and N-terminal sequence of rabbit antibodies. J. biol. Chem. 214: 185 1955; 10 Davies M. C, Englert M. E. Physical properties of highly purified human plasminogen. J. biol. Chem. 235: 1011 1960; 11 Rifé U, Shulman S. Molecular changes in activation of plasminogen. Fed. Proc. 19: 59 1960; 12 Shulman S, Rife U. Some aspects of the plasminogen activation mechanism. Thromb Diath. haem. in press..
