Thrombosis and Haemostasis, Inhaltsverzeichnis Thromb Haemost 1962; 08(02): 315-321DOI: 10.1055/s-0038-1655431 Originalarbeiten – Original Articles – Travaux Originaux Schattauer GmbH The Measurement of Fibrinolytic Activity with I131-labelled Clots. I. The Methods[*] Authors Institutsangaben C. Dudok de Wit 1 Central Laboratory of the Netherlands Red Cross Blood Transfusion Service (Director: Prof. Dr. J. J. van Loghem) H. W Krijnen 1 Central Laboratory of the Netherlands Red Cross Blood Transfusion Service (Director: Prof. Dr. J. J. van Loghem) G. J. H den Ottolander 1 Central Laboratory of the Netherlands Red Cross Blood Transfusion Service (Director: Prof. Dr. J. J. van Loghem) Artikel empfehlen Abstract als PDF herunterladen(opens in new window) Artikel einzeln kaufen(opens in new window) Summary The technical details of a method for the measurement of fibrinolytic activity with I131-labelled clots are described. The advantages of this modification of the method of Alkjaersig are discussed. PDF (6721 kb) Referenzen References 1 Astrup T, Müllertz S. The fibrin plate method for estimating fibrinolytic activity. Arch. Biochem. 1952; 40: 346 2 Alkjaersig N. P, Fletcher P, Sherry S. The mechanism of clot dissolution by plasmin. J. clin. Invest. 1959; 38: 1086 3 Blombäck B, Blombäck M. Purification of human and bovine fibrinogen. Ark. Kemi 1956; 10: 415 4 Remmert L. F, Cohen P. P. Partial purification and properties of a proteolytic enzyme of human serum. J. biol. Chem. 1949; 181: 431 5 Norman P. S. Studies of the plasmin system. I. Measurement of human and animal plasminogen. Measurement of an activator in human serum. J. exp. Med. 1957; 106: 423 6 Derechin M. The assay of human plasminogen with casein as a substrate. Biochem. J. 1961; 78: 443 7 de Zoeten L. W. Onderzoek over de reactiviteit ten opzichte van jodium van de onderscheidene tyrosineresten van insuline. Leiden, Thesis 1959 8 van Doesburgh I. Th. Insuline I131 . Leiden, Thesis 1962 9 Shulman N. R, Tagnon H. J. Proteolytic activity determined with a substrate tagged with radioactive iodine. J. biol. Chem. 186: 69 1950; 10 Clement W. E, McNicol A. P. The preparation and use of I131-tagged fibrinogen to demonstrate fibrinolysis. J. clin. Path. 1959; 12: 544