Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1957; 01(02): 153-157DOI: 10.1055/s-0038-1656168 Originalarbeiten – Original Article – Travaux Originaux Schattauer GmbH Deficiency of the Hageman Factor Demonstrated by the Thrombin Generation Test Knud-Erik Sjølin 1 Biological Institute of the Carlsberg Foundation, Copenhagen, and the Institute of Human Genetics, University of Copenhagen, Denmark› Author AffiliationsRecommend Article Abstract Summary A coagulation defect in the plasma from a 37 year old man with no bleeding symptoms is described. The defect was revealed by the thrombin generation test and seemed to be caused by lack of the Hageman factor. The coagulation defect could be corrected by freezing of the plasma. Full Text References References 1 Biggs R, and Macfarlane R. G. Human Blood Coagulation and its Disorders. Blackwell Scientific Publications; Oxford: 1953 2 Brodthagen H. The Preparation of Prothrombinfree Ox Plasma in the Estimation of Prothrombin. Scand. J. clin. Lab. Invest. 5: 376 1953; 3 Frick P. G, and Hägen P. S. Severe Coagulation Defect without Haemorrhagic Symptoms Caused by a Deficiency of the Fifth Plasma Thromboplastin Precursor. J. Lab. clin. Med. 48: 592 1956; 4 Macfarlane R. G, and Biggs R. A Thrombin Generation Test. J. clin. Path. 6: 3 1953; 5 Pitney W. R, and Dacie J. V. A Simple Method of Studying the Generation of Thrombin in Recalcified Plasma. J. clin. Path. 6: 9 1953; 6 Ratnoff O. D, and Colopy J. E. A Familial Haemorrhagic Trait Associated with a Deficiency of a Clot-Promoting Factor of Plasma. J. clin. Invest. 4: 602 1955; 7 Ratnoff O. D, and Margoliusjun A. Hageman Trait: An Asymptomatic Disorder of Blood Coagulation. Trans. Assoc. Amer. Phys. 67: 149 1955; 8 Sjølin K.-E. The Thrombin Generation Test in the Diagnosis of Classical Haemophilia and Christmas Disease. Scand. J. clin. Lab. Invest. 8: 138 1956; a 9 Sjølin K.-E. Deficiency of a Factor in the Plasma Thromboplastin System Revealed by Freezing of the Plasma. Danish Medical Bulletin 3: 222 1956; b
