Platelet Sequestration During Hypothermia in Dogs Treated with Sulphinpyrazone and Ticlopidine - Reversibility Accelerated After Intra-Abdominal Rewarming

J M Pina-Cabral; A Ribeiro-da-Silva; A Almeida-Dias

doi:10.1055/s-0038-1660144

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1985; 54(04): 838-841
DOI: 10.1055/s-0038-1660144

Original Article

Schattauer GmbH Stuttgart

Platelet Sequestration During Hypothermia in Dogs Treated with Sulphinpyrazone and Ticlopidine - Reversibility Accelerated After Intra-Abdominal Rewarming

Authors

J M Pina-Cabral

The Centro de Fisiologia da Hemóstase (INIC), Depts. of Physiology and Histology and Embryology, Porto Medical School, Hospital de S. Joäo, Porto, Portugal
A Ribeiro-da-Silva

The Centro de Fisiologia da Hemóstase (INIC), Depts. of Physiology and Histology and Embryology, Porto Medical School, Hospital de S. Joäo, Porto, Portugal
A Almeida-Dias

The Centro de Fisiologia da Hemóstase (INIC), Depts. of Physiology and Histology and Embryology, Porto Medical School, Hospital de S. Joäo, Porto, Portugal

Abstract

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Summary

During body cooling, a progressive thrombocytopenia is observed, with platelet sequestration mainly in the liver. Platelets return progressively to the circulation during re warming. In this work the presence of platelet clumps is demonstrated by electron microscopy inside the hepatic sinusoids of dogs cooled to 20° C by immersion in iced water. Such clumps were not found either before cooling or after body rewarming. Similar platelet clumps in the hepatic microcirculation were found in two other groups of dogs cooled and rewarmed as before, but previously treated with the antiaggregants sulphinpyrazone or ticlopidine. Another group of dogs was cooled and rewarmed by intra-abdominal circulation of physiological saline respectively at 4° C and 40° C. In these animals a similar decrease of circulating platelets was observed. However, just after re warming was started, with the body temperature still at 22° C, sequestered platelets came back abruptly to circulation. We conclude that hepatic platelet sequestration induced by hypothermia appears mainly due to local haemodynamic conditions.

Key words

Hypothermia - Platelet sequestration - Sulphinpyrazone - Ticlopidine

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References

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