Summary
A quantitative model of venous thrombosis in the beagle dog is described. The model
was adapted to permit ageing of isolated experimental clots in vivo. A model of acute
pulmonary embolism in this species is also described. In the venous thrombosis model,
infusion of streptokinase (SK) or SK-activated human plasmin gave significant lysis
but bolus doses of SK. plasmin complex were ineffective. Active site anisoylated derivatives
of SK. plasminogen complex, SK-activated plasmin and activator-free plasmin were all
active when given as bolus doses in both models. At lytic doses, the acyl-enzymes
caused fewer side-effects attributable to plasminaemia than the corresponding unmodified
enzymes.
Keywords
Thrombolysis - Venous thrombosis - Pulmonary embolism - Dogs - Acylated enzymes
