Platelets may contribute to the pathogenesis of atherosclerosis and to the complications
of coronary artery disease. Therefore, platelet kinetics were studied in 69 patients
with angiographically documented coronary artery disease and in 16 patients with a
normal coronary angiogram. Platelet survival time was calculated from the decay of
radioactivity after injection of 51Cr-labeled autologous platelets. None of the mathematical models used was able to
discriminate between the two patients groups. No correlation existed between survival
time and extent of the arterial disease. Patients with a high serum cholesterol did
not exhibit an enhanced platelet consumption. Thus, these studies do not support the
idea that platelet turnover is enhanced in patients with coronary artery disease as
compared to those with normal coronary arteries.
Keywords
Blood platelets - Coronary disease - Angina pectoris - Arteriosclerosis
