The “Aspirin Dilemma”: New Points for Discussion

• References

• 1 Marcus AJ. Editorial retrospective. Aspirin as an antithrombotic medication N Engl J Med 1984; 309: 1515-1517
• 2 Ali M, McDonald JW D, Thiessen JJ, Coates PE. Plasma acetylsalicylate and salicylate and platelet cyclooxygenase activity following plain and enteric-coated aspirin. Stroke 1980; 11: 9-13
• 3 Siebert DJ, Bochner F, Imhoff DM, Watts S, Lloyd JV, Field J, Gabb BW. Aspirin kinetics and platelet aggregation in man. Clin Pharmacol Ther 1983; 33: 367-374
• 4 Cerletti C, Latini R, Del Maschio A, Galletti F, Dejana E, de Gaetano G. Aspirin formulations that deliver no acetylsalicylic acid to the peripheral circulation: A possible resolution of the “aspirin dilemma”. Proc Symp “Prostacyclin: New Basic and Clinical Studies”. Karash N, Watkins GL. (Eds) (in press)
• 5 Fitzgerald GA. Novel aspects of aspirin action. 4th International Washington Spring Symposium may 8-12. Washington: 1984. Abstr 52
• 6 Lysz TW, Needleman P. Evidence for two distinct forms of fatty acid cyclooxygenase in brain. J Neurochem 1982; 38: 1111-1117
• 7 Willems C, De Groot PG, Pool GA, Gonsalvez MS, Van Aken WG, Van Mourik JA. Arachidonate metabolism in cultured human vascular endothelial cells. Evidence for two prostaglandin synthetic pathways sensitive to acetylsalicylic acid Biochim Biophys Acta 1982; 713: 581-588
• 8 Livio M, Rajtar G, Merino J, de Gaetano G. Malondialdehyde formation in rat platelet-rich plasma. Thromb Haemostas 1980; 44: 52-55
• 9 Reimers H-J, Scharf RE, Baker RK. Thrombin pretreatment of human platelets impairs thromboxane A₂ synthesis from endogenous precursors in the presence of normal cyclooxygenase activity. Blood 1984; 63: 858-865
• 10 Dejana E, Balconi G, De Castellamau C, Barbieri B, Vergara-Dauden M, de Gaetano G. Prostacyclin production by human endothelial and bovine smooth muscle cells in culture. Effect of repeated stimulation with arachidonic acid, thrombin and the ionophore A23187 Biochim Biophys Acta 1983; 750: 261-267
• 11 Dejana E, Cerletti C, De Castellamau C, Livio M, Galletti F, Latini R, de Gaetano G. Salicylate-aspirin interaction in the rat. Evidence that salicylate accumulating during aspirin administration may protect vascular prostacyclin from aspirin-induced inhibition J Clin Invest 1981; 68: 1108-1112
• 12 Cerletti C, Bonati M, Del Maschio A, Galletti F, Dejana E, Tognoni G, de Gaetano G. Plasma levels of salicylate and aspirin in healthy subjects: relevance to drug interaction on platelet function. J Lab Clin Med 1984; 103: 869-877
• 13 Siegel MI, McConnell RT, Cuatrecasas P. Aspirin-like drugs interfere with arachidonate metabolism by inhibition of the 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid peroxidase activity of the lipoxygenase pathway. Proc Natl Acad Sci USA 1979; 76: 3774-3778
• 14 Villa S, Colotta F, de Gaetano G, Semeraro N. Arachidonic acid and leukotriene B₄ induce aggregation of human peripheral blood mononuclear leukocyte in vitro. Br J Haematol 1984; 58: 137-146
• 15 Mullane KM, Read N, Salmon JA, Moncada S. Role of leukocytes in acute myocardial infarction in anesthetized dogs: Relationship to myocardial salvage by anti-inflammatory drugs. J Pharmacol Exp Ther 1984; 228: 510-522
• 16 Marcus AJ, Broekman MJ, Safier LB, Ullman HL, Islam N, Serhan CN, Weissmann G. Production of arachidonic acid lipoxygenase products during platelet-neutrophil interactions. Clin Physiol Biochem 1984; 2: 78-83