A factor VIII inhibitor has been found in a patient with an unusual combination of
factor VIII-related properties. The inhibitor is directed specifically against the
clotting activity (VIII :C) of the factor VIII complex. It behaves in a similar fashion
to high responding inhibitors of factor VIII seen in haemophilia A patients and it
was characterised as an immunoglobulin of the IgG class. Laboratory results from the
patient and his family show considerable variation of factor VUI-related properties
between various individuals. Overall, the data suggests the co-existence of haemophilia
A and von Willebrand’s disease in the family and the presence of both diseases in
the patient.
Key words
Haemophilia A - von Willebrand’s disease - Factor VIII inhibitor
