Perinatal Protein Undernutrition and Cardiovascular System: A Systematic Review

José Emerson Xavier; Erivaldo Alves Antonio; Lisiane dos Santos Oliveira; Sandra Lopes de Souza; Juliana Pinto de Medeiros; Lavínia Calmon Lima; Carlos Alberto de Carvalho Fraga; Rafael Danyllo da Silva Miguel

doi:10.1055/s-0038-1675361

Journal of Morphological Sciences, Table of Contents

CC BY-NC-ND 4.0 · Journal of Morphological Sciences 2018; 35(04): 203-206
DOI: 10.1055/s-0038-1675361

Review Article

Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Perinatal Protein Undernutrition and Cardiovascular System: A Systematic Review

Authors

José Emerson Xavier

¹Department of Histology and Embryology, Centro de Biociências, Universidade Federal de Pernambuco, Recife, PE, Brazil
Erivaldo Alves Antonio

¹Department of Histology and Embryology, Centro de Biociências, Universidade Federal de Pernambuco, Recife, PE, Brazil
Lisiane dos Santos Oliveira

²Department of Nursery, Centro Acadêmico de Vitória, Universidade Federal de Pernambuco, Vitória de Santo Antão, PE, Brazil
Sandra Lopes de Souza

³Departament of Anatomy, Centro de Biociências, Universidade Federal de Pernambuco, Recife, PE, Brasil
Juliana Pinto de Medeiros

¹Department of Histology and Embryology, Centro de Biociências, Universidade Federal de Pernambuco, Recife, PE, Brazil
Lavínia Calmon Lima

⁴Department of Medicine, Universidade Federal de Alagoas, Arapiraca, AL, Brazil
Carlos Alberto de Carvalho Fraga

⁴Department of Medicine, Universidade Federal de Alagoas, Arapiraca, AL, Brazil
Rafael Danyllo da Silva Miguel

⁴Department of Medicine, Universidade Federal de Alagoas, Arapiraca, AL, Brazil

Abstract

The present study is a systematic review of the literature that aimed to characterize the profile in animal models used to study perinatal protein malnutrition correlating with the cardiovascular system and the implications of malnutrition to the heart. Therefore, an extensive search was conducted in the PubMed, BVS, and SciELO databases, using combinations of the descriptors protein malnutrition, pregnancy, heart, lactation, and cardiovascular system. A total of 247 articles were found, but after excluding duplicities and applying the inclusion/exclusion criteria, only 12 papers remained. The analysis of the results shows that the diet used in the studies has a protein content of between 17 and 22% for the control animals, and of between 0 and 9% for the animals submitted to perinatal protein malnutrition. The main morphofunctional changes observed in the cardiovascular system are related to high blood pressure, increased apoptosis of cardiomyocytes, and reduction in the absolute size of the heart, among other ultrastructural and molecular changes.

Keywords

cardiovascular diseases - heart - offspring - undernutrition

Full Text

References

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