Abstract
Hepatic angiosarcoma and epithelioid hemangioendothelioma (EHE) might be clinically
considered a spectrum since, although more frequently presenting indolent behavior,
EHE occasionally evolves to high-grade neoplasms. However, in most circumstances,
pathological and immunohistochemical patterns define this differential diagnosis.
More recently, molecular pathways for angiosarcoma and for EHE from other organs and
from soft tissue have been proved different, paving the way for future morpho-molecular
assessment of their hepatic counterpart. The frequency of liver involvement by Kaposi
sarcoma in HIV-infected patients is lower nowadays. Histological findings and immunostaining
for HHV-8 Ag are characteristic. Hepatic small vessel neoplasms have been recently
recognized as important mimickers of angiosarcoma. The criteria for this differential
diagnosis and the clinical behavior, up to now considered favorable, must be further
studied.
Keywords
angiosarcoma - epithelioid hemangioendothelioma - hepatic small vessel neoplasm -
Kaposi's sarcoma - pathology - molecular pathogenesis
