Abstract
Background Aspirin is the oldest and possibly the most widely used pharmacologically active
substance still used in allopathic medicine. Its effect on fever and inflammation
has paved the way to its anti-thrombotic effect. Dilutions of aspirin have been tested
for many years in the University of Bordeaux, in humans as well as in animal models.
Methods This article is a review of the totality of articles published by the Laboratory
of Hematology of the Faculty of Pharmacy of the University of Bordeaux, reporting
different doses and dilutions of aspirin, different kinds of inhibitors, transgenic
mice and animal models of disease such as portal hypertension and cirrhosis.
Results Homeopathic dilutions of aspirin, notably 15 cH, have shown a pro-thrombotic effect
in humans and in in-vivo animal studies. Longitudinal studies in rats have also shown
an initial anti-thrombotic effect followed by a pro-thrombotic effect of aspirin several
days after a single high-dose administration. This pro-thrombotic effect seems to
act by inhibiting the cyclooxygenase (COX)-2 pathway in studies performed with COX
selective inhibitors and in knock-out mice without COX-1 or COX-2. This effect may
explain the thrombo-embolic complications described after aspirin withdrawal for the
purposes of surgery or after non-compliance with anti-platelet therapy, and it may
be beneficial in normalising primary haemostasis and decreasing haemorrhage in animal
models of portal hypertension and cirrhosis.
Conclusions Aspirin 15 cH acts through the inhibition of the COX-2 pathway producing a clear
pro-thrombotic effect. Further studies should clarify if the pro-thrombotic effect
of aspirin withdrawal and the effect of aspirin 15 cH are related, as secondary effects
of the same drug. Clarifying this last outcome may be of great significance to public
health.
Keywords
aspirin 15 cH - thrombosis - portal hypertension - homeopathy - COX inhibition - aspirin
withdrawal
