Am J Perinatol 2020; 37(04): 370-374
DOI: 10.1055/s-0039-1678603
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Obstetric Outcomes in Young Women with Breast Cancer: Prior, Postpartum, and Subsequent Pregnancies

Kimberly K. Ma
1  Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington
,
Courtney J. Preusse
2  Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington
,
Philip A. Stevenson
2  Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington
,
Veronica L. Winget
2  Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington
,
Jean A. McDougall
3  Division of Epidemiology, Biostatistics, and Preventive Medicine, University of New Mexico, Albuquerque, New Mexico
4  Cancer Control and Population Sciences Program, University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico
,
Christopher I. Li
2  Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington
,
Vijayakrishna K. Gadi*
2  Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington
5  Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington
6  Division of Medical Oncology, University of Washington, Seattle, Washington
,
Hilary S. Gammill*
1  Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington
2  Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington
› Author Affiliations
Funding Support This study was funded by grants NIH HD067221 (H.S.G.) and NIH 1P50CA138293–01A1 (V.K.G.).
Further Information

Publication History

11 September 2018

09 January 2019

Publication Date:
06 February 2019 (online)

Abstract

Objective This study aimed to describe obstetric outcomes in a large cohort of young women with breast cancer, considering the chronological relationship of pregnancies with breast cancer diagnosis.

Study Design From a population-based cohort study of young women with breast cancer from 2004 to 2010, we conducted secondary interviews to obtain detailed obstetric histories. Pregnancies were categorized based on timing of breast cancer diagnosis: prior, postpartum, and subsequent pregnancies after breast cancer diagnosis. A generalized estimated equation model was used to account for correlated data.

Results In this cohort (n = 366), median age at breast cancer diagnosis was 40.1 years, and 84.7% were Caucasian. Tumor type was notable for 25.1% triple negative, and 56.1% had Stage I disease. There were 922 prior pregnancies, 21 with postpartum diagnosis of breast cancer, and 24 pregnancies subsequent to breast cancer diagnosis. Non-live birth outcomes occurred significantly more often in the postpartum group (p-value: 0.001) compared with the other groups, which had higher live birth rates, after adjustment for maternal age, parity, body mass index, and race.

Conclusion Overall, pregnancy outcomes before and after breast cancer diagnosis are reassuring.

* These authors contributed equally to this article.