Obstetric Outcomes in Young Women with Breast Cancer: Prior, Postpartum, and Subsequent Pregnancies

Kimberly K. Ma; Courtney J. Preusse; Philip A. Stevenson; Veronica L. Winget; Jean A. McDougall; Christopher I. Li; Vijayakrishna K. Gadi; Hilary S. Gammill

doi:10.1055/s-0039-1678603

American Journal of Perinatology, Table of Contents

Am J Perinatol 2020; 37(04): 370-374
DOI: 10.1055/s-0039-1678603

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Obstetric Outcomes in Young Women with Breast Cancer: Prior, Postpartum, and Subsequent Pregnancies

Authors

Kimberly K. Ma

¹Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington
Courtney J. Preusse

²Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington
Philip A. Stevenson

²Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington
Veronica L. Winget

²Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington
Jean A. McDougall

³Division of Epidemiology, Biostatistics, and Preventive Medicine, University of New Mexico, Albuquerque, New Mexico

⁴Cancer Control and Population Sciences Program, University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico
Christopher I. Li

²Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington
Vijayakrishna K. Gadi^*

²Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington

⁵Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington

⁶Division of Medical Oncology, University of Washington, Seattle, Washington
Hilary S. Gammill^*

¹Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington

²Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington

Abstract

Objective This study aimed to describe obstetric outcomes in a large cohort of young women with breast cancer, considering the chronological relationship of pregnancies with breast cancer diagnosis.

Study Design From a population-based cohort study of young women with breast cancer from 2004 to 2010, we conducted secondary interviews to obtain detailed obstetric histories. Pregnancies were categorized based on timing of breast cancer diagnosis: prior, postpartum, and subsequent pregnancies after breast cancer diagnosis. A generalized estimated equation model was used to account for correlated data.

Results In this cohort (n = 366), median age at breast cancer diagnosis was 40.1 years, and 84.7% were Caucasian. Tumor type was notable for 25.1% triple negative, and 56.1% had Stage I disease. There were 922 prior pregnancies, 21 with postpartum diagnosis of breast cancer, and 24 pregnancies subsequent to breast cancer diagnosis. Non-live birth outcomes occurred significantly more often in the postpartum group (p-value: 0.001) compared with the other groups, which had higher live birth rates, after adjustment for maternal age, parity, body mass index, and race.

Conclusion Overall, pregnancy outcomes before and after breast cancer diagnosis are reassuring.

Keywords

breast cancer - pregnancy - obstetric outcomes

Full Text

References

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