The Ultimate Murine Model of Immune Thrombocytopaenia

John W. Semple; Rick Kapur

doi:10.1055/s-0039-1678697

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2019; 119(03): 353-354
DOI: 10.1055/s-0039-1678697

Invited Editorial Focus

Georg Thieme Verlag KG Stuttgart · New York

The Ultimate Murine Model of Immune Thrombocytopaenia

Authors

John W. Semple

¹Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden
Rick Kapur

²Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

Abstract

Volltext

Referenzen

References
1 Rodeghiero F, Stasi R, Gernsheimer T. , et al. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood 2009; 113 (11) 2386-2393
2 Zufferey A, Kapur R, Semple JW. Pathogenesis and therapeutic mechanisms in immune thrombocytopenia (ITP). J Clin Med 2017; 6 (02) E16
3 McKenzie CG, Guo L, Freedman J, Semple JW. Cellular immune dysfunction in immune thrombocytopenia (ITP). Br J Haematol 2013; 163 (01) 10-23
4 Harrington WJ, Minnich V, Hollingsworth JW, Moore CV. Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura. J Lab Clin Med 1951; 38 (01) 1-10
5 Olsson B, Andersson PO, Jernås M. , et al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med 2003; 9 (09) 1123-1124
6 Crow AR, Song S, Semple JW, Freedman J, Lazarus AH. IVIg inhibits reticuloendothelial system function and ameliorates murine passive-immune thrombocytopenia independent of anti-idiotype reactivity. Br J Haematol 2001; 115 (03) 679-686
7 Chow L, Aslam R, Speck ER. , et al. A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy. Blood 2010; 115 (06) 1247-1253
8 Aslam R, Hu Y, Gebremeskel S. , et al. Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia. Blood 2012; 120 (10) 2127-2132
9 Aslam R, Kapur R, Segel GB. , et al. The spleen dictates platelet destruction, anti-platelet antibody production, and lymphocyte distribution patterns in a murine model of immune thrombocytopenia. Exp Hematol 2016; 44 (10) 924-930
10 Guo L, Kapur R, Aslam R. , et al. Antiplatelet antibody-induced thrombocytopenia does not correlate with megakaryocyte abnormalities in murine immune thrombocytopenia. Scand J Immunol 2018; 88 (01) e12678
11 Guo L, Kapur R, Aslam R. , et al. CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia. Blood 2016; 127 (06) 735-738
12 Guo L, Yang L, Speck ER. , et al. Allogeneic platelet transfusions prevent murine T-cell-mediated immune thrombocytopenia. Blood 2014; 123 (03) 422-427
13 Kapur R, Catalina MD, Aslam R, Speck ER, Francovitch RF, Semple JW. A highly purified form of staphylococcal protein A alleviates murine immune thrombocytopenia (ITP). Br J Haematol 2018; 183 (03) 501-503
14 Kapur R, Aslam R, Kim M. , et al. Thymic-derived tolerizing dendritic cells are upregulated in the spleen upon treatment with intravenous immunoglobulin in a murine model of immune thrombocytopenia. Platelets 2017; 28 (05) 521-524
15 Hou Y, Feng Q, Xu M. , et al. High-dose dexamethasone corrects impaired myeloid-derived suppressor cell function via Ets1 in immune thrombocytopenia. Blood 2016; 127 (12) 1587-1597
16 Zufferey A, Speck ER, Machlus KR. , et al. Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets. Blood Adv 2017; 1 (20) 1773-1785
17 Li X, Wang SW, Feng Q. , et al. Novel murine model of immune thrombocytopaenia through immunized CD41 knockout mice. Thromb Haemost 2019 119. (03). Doi: 10.1055/s-0038-1677032
18 Hodivala-Dilke KM, McHugh KP, Tsakiris DA. , et al. Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J Clin Invest 1999; 103 (02) 229-238