Abstract
Objective To evaluate whether real-time continuous glucose monitoring improves glycemic control
over intermittent self-monitoring of blood glucose in gestational diabetes.
Study Design We performed a single-institution randomized controlled trial. Patients with gestational
diabetes were randomized to use either real-time or blinded continuous glucose monitoring.
The primary outcome was mean sensor glucose level during the fourth week of continuous
glucose monitoring use. Secondary outcomes included glycemic control and a composite
of obstetric and neonatal outcomes.
Results Of the 40 enrolled patients, 12 (60%) patients in the blinded continuous glucose
monitoring group and 11 (55%) in the real-time continuous glucose monitoring group
completed 4 weeks of monitoring and were included in the final analysis. There was
no significant difference in mean sensor glucose level between the blinded continuous
glucose monitoring group (98.9 ± 8.9 mg/dL) and the real-time continuous glucose monitoring
group (107.5 ± 11.4 mg/dL). There were also no significant differences in the time
spent in glycemic target, maternal, or neonatal outcomes.
Conclusion Our study shows that the use of continuous glucose monitoring with real-time feedback
did not significantly decrease mean glucose values compared with intermittent self-monitoring
of blood glucose after 4 weeks of continuous glucose monitoring use.
Keywords
gestational diabetes - diabetes - pregnancy - continuous glucose monitoring - glucose
monitoring
