The Journal of Hip Surgery 2019; 03(01): 034-040
DOI: 10.1055/s-0039-1678743
Special Section Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Metastatic Disease, Myeloma, and Lymphoma Affecting the Hip

Arianna L. Gianakos
1   Department of Orthopaedic Surgery, Jersey City Medical Center - RWJBarnabas Health, Jersey City, New Jersey
,
Jay N. Patel
2   Division of Orthopaedic Oncology, Department of Orthopaedic Surgery, Morristown Medical Center – Atlantic Health System, Morristown, New Jersey
,
Justin M. Miller
1   Department of Orthopaedic Surgery, Jersey City Medical Center - RWJBarnabas Health, Jersey City, New Jersey
,
Laura Sonnylal
3   Department of Orthopaedic Surgery, Hackensack University Medical Center, Hackensack, New Jersey
,
James C. Wittig
2   Division of Orthopaedic Oncology, Department of Orthopaedic Surgery, Morristown Medical Center – Atlantic Health System, Morristown, New Jersey
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Weitere Informationen

Publikationsverlauf

31. August 2018

06. November 2018

Publikationsdatum:
15. Februar 2019 (online)

Abstract

The three most common causes for bony lesions in patients over 40 years of age are metastatic disease, multiple myeloma, and lymphoma. Oftentimes, these conditions have a predilection for the hip region. The authors present the incidence, characteristics, and treatment of metastatic disease, multiple myeloma, and lymphoma affecting the hip joint to help clinicians accurately diagnose and manage these conditions. They also present the senior author's technique of cemented long stem hemiarthroplasty for treating these conditions when they affect the proximal femur.

 
  • References

  • 1 Decaux O, Lodé L, Minvielle S, Avet-Loiseau H. [Genetic abnormalities in multiple myeloma: role in oncogenesis and impact on survival]. Rev Med Interne 2007; 28 (10) 677-681
  • 2 Avet-Loiseau H. Role of genetics in prognostication in myeloma. Best Pract Res Clin Haematol 2007; 20 (04) 625-635
  • 3 Sergentanis TN, Zagouri F, Tsilimidos G. , et al. Risk factors for multiple myeloma: a systematic review of meta-analyses. Clin Lymphoma Myeloma Leuk 2015; 15 (10) 563-77.e1 , 3
  • 4 Rajkumar SV, Kyle RA. Treatment of multiple myeloma and related disorders. Cambridge; New York: Cambridge University Press; 2009
  • 5 Melton III LJ, Kyle RA, Achenbach SJ, Oberg AL, Rajkumar SV. Fracture risk with multiple myeloma: a population-based study. J Bone Miner Res 2005; 20 (03) 487-493
  • 6 Roodman GD. Mechanisms of bone metastasis. N Engl J Med 2004; 350 (16) 1655-1664
  • 7 Kyle RA. Multiple myeloma: review of 869 cases. Mayo Clin Proc 1975; 50 (01) 29-40
  • 8 Gleeson TG, Moriarty J, Shortt CP. , et al. Accuracy of whole-body low-dose multidetector CT (WBLDCT) versus skeletal survey in the detection of myelomatous lesions, and correlation of disease distribution with whole-body MRI (WBMRI). Skeletal Radiol 2009; 38 (03) 225-236
  • 9 Princewill K, Kyere S, Awan O, Mulligan M. Multiple myeloma lesion detection with whole body CT versus radiographic skeletal survey. Cancer Invest 2013; 31 (03) 206-211
  • 10 Wolf MB, Murray F, Kilk K. , et al. Sensitivity of whole-body CT and MRI versus projection radiography in the detection of osteolyses in patients with monoclonal plasma cell disease. Eur J Radiol 2014; 83 (07) 1222-1230
  • 11 Moulopoulos LA, Dimopoulos MA, Weber D, Fuller L, Libshitz HI, Alexanian R. Magnetic resonance imaging in the staging of solitary plasmacytoma of bone. J Clin Oncol 1993; 11 (07) 1311-1315
  • 12 Baur A, Stäbler A, Brüning R. , et al. Diffusion-weighted MR imaging of bone marrow: differentiation of benign versus pathologic compression fractures. Radiology 1998; 207 (02) 349-356
  • 13 Zamagni E, Nanni C, Patriarca F. , et al. A prospective comparison of 18F-fluorodeoxyglucose positron emission tomography-computed tomography, magnetic resonance imaging and whole-body planar radiographs in the assessment of bone disease in newly diagnosed multiple myeloma. Haematologica 2007; 92 (01) 50-55
  • 14 Regelink JC, Minnema MC, Terpos E. , et al. Comparison of modern and conventional imaging techniques in establishing multiple myeloma-related bone disease: a systematic review. Br J Haematol 2013; 162 (01) 50-61
  • 15 Terpos E, Morgan G, Dimopoulos MA. , et al. International Myeloma Working Group recommendations for the treatment of multiple myeloma-related bone disease. J Clin Oncol 2013; 31 (18) 2347-2357
  • 16 Palumbo A, Sezer O, Kyle R. , et al; IMWG. International Myeloma Working Group guidelines for the management of multiple myeloma patients ineligible for standard high-dose chemotherapy with autologous stem cell transplantation. Leukemia 2009; 23 (10) 1716-1730
  • 17 Mhaskar R, Kumar A, Miladinovic B, Djulbegovic B. Bisphosphonates in multiple myeloma: an updated network meta-analysis. Cochrane Database Syst Rev 2017; 12: CD003188
  • 18 Raje N, Terpos E, Willenbacher W. , et al. Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: an international, double-blind, double-dummy, randomised, controlled, phase 3 study. Lancet Oncol 2018; 19 (03) 370-381
  • 19 Scharschmidt TJ, Lindsey JD, Becker PS, Conrad EU. Multiple myeloma: diagnosis and orthopaedic implications. J Am Acad Orthop Surg 2011; 19 (07) 410-419
  • 20 Steinbach M, Richards T, Faiman B. Strategies for selecting the optimal treatment in newly diagnosed multiple myeloma patients. Semin Oncol Nurs 2017; 33 (03) 254-264
  • 21 Mateos MV, San Miguel JF. Management of multiple myeloma in the newly diagnosed patient. Hematology (Am Soc Hematol Educ Program) 2017; 2017 (01) 498-507
  • 22 Alvi HM, Damron TA. Prophylactic stabilization for bone metastases, myeloma, or lymphoma: do we need to protect the entire bone?. Clin Orthop Relat Res 2013; 471 (03) 706-714
  • 23 Utzschneider S, Schmidt H, Weber P, Schmidt GP, Jansson V, Dürr HR. Surgical therapy of skeletal complications in multiple myeloma. Int Orthop 2011; 35 (08) 1209-1213
  • 24 Harrington KD. New trends in the management of lower extremity metastases. Clin Orthop Relat Res 1982; (169) 53-61
  • 25 Levy RN, Sherry HS, Siffert RS. Surgical management of metastatic disease of bone at the hip. Clin Orthop Relat Res 1982; (169) 62-69
  • 26 D'Antonio JA, Capello WN, Borden LS. , et al. Classification and management of acetabular abnormalities in total hip arthroplasty. Clin Orthop Relat Res 1989; (243) 126-137
  • 27 Angtuaco EJ, Fassas AB, Walker R, Sethi R, Barlogie B. Multiple myeloma: clinical review and diagnostic imaging. Radiology 2004; 231 (01) 11-23
  • 28 Ludwig H, Durie BG, Bolejack V. , et al. Myeloma in patients younger than age 50 years presents with more favorable features and shows better survival: an analysis of 10 549 patients from the International Myeloma Working Group. Blood 2008; 111 (08) 4039-4047
  • 29 Parikh SN, Kreder HJ. Pelvic reconstruction for massive acetabular insufficiency. Clin Orthop Relat Res 2005; (434) 217-221
  • 30 Freeman C, Berg JW, Cutler SJ. Occurrence and prognosis of extranodal lymphomas. Cancer 1972; 29 (01) 252-260
  • 31 Limb D, Dreghorn C, Murphy JK, Mannion R. Primary lymphoma of bone. Int Orthop 1994; 18 (03) 180-183
  • 32 Newcomer LN, Silverstein MB, Cadman EC, Farber LR, Bertino JR, Prosnitz LR. Bone involvement in Hodgkin's disease. Cancer 1982; 49 (02) 338-342
  • 33 Binesh F, Mirjalili MR, Akhavan A, Navabii H. Primary bony Hodgkin's lymphoma. BMJ Case Rep 2012; 2012: 201
  • 34 Tang F, Min L, Ye Y. , et al. Classic Hodgkin lymphoma in pelvis: a case report highlights diagnosis and treatment challenges. Medicine (Baltimore) 2017; 96 (39) e8196
  • 35 Fletcher CDM. , World Health Organization. International Agency for Research on Cancer. WHO Classification of Tumours of Soft Tissue and Bone. 4th ed. Lyon: IARC Press; 2013
  • 36 Auerbach A, Aguilera NS. Epstein-Barr virus (EBV)-associated lymphoid lesions of the head and neck. Semin Diagn Pathol 2015; 32 (01) 12-22
  • 37 Vockerodt M, Yap LF, Shannon-Lowe C. , et al. The Epstein-Barr virus and the pathogenesis of lymphoma. J Pathol 2015; 235 (02) 312-322
  • 38 Linke-Serinsöz E, Fend F, Quintanilla-Martinez L. Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) related lymphomas, pathology view point. Semin Diagn Pathol 2017; 34 (04) 352-363
  • 39 Paydas S. Hepatitis C virus and lymphoma. Crit Rev Oncol Hematol 2015; 93 (03) 246-256
  • 40 Schinasi L, Leon ME. Non-Hodgkin lymphoma and occupational exposure to agricultural pesticide chemical groups and active ingredients: a systematic review and meta-analysis. Int J Environ Res Public Health 2014; 11 (04) 4449-4527
  • 41 Czarnota J, Gennings C, Colt JS. , et al. Analysis of environmental chemical mixtures and non-Hodgkin lymphoma risk in the NCI-SEER NHL study. Environ Health Perspect 2015; 123 (10) 965-970
  • 42 Lauby-Secretan B, Loomis D, Grosse Y. , et al; WHO International Agency for Research on Cancer. Carcinogenicity of polychlorinated biphenyls and polybrominated biphenyls. Lancet Oncol 2013; 14 (04) 287-288
  • 43 Carbone PP, Kaplan HS, Musshoff K, Smithers DW, Tubiana M. Report of the committee on Hodgkin's disease staging classification. Cancer Res 1971; 31 (11) 1860-1861
  • 44 Lister TA, Crowther D, Sutcliffe SB. , et al. Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin's disease: Cotswolds meeting. J Clin Oncol 1989; 7 (11) 1630-1636
  • 45 Demircay E, Hornicek Jr FJ, Mankin HJ, Degroot III H. Malignant lymphoma of bone: a review of 119 patients. Clin Orthop Relat Res 2013; 471 (08) 2684-2690
  • 46 Beal K, Allen L, Yahalom J. Primary bone lymphoma: treatment results and prognostic factors with long-term follow-up of 82 patients. Cancer 2006; 106 (12) 2652-2656
  • 47 Habermann ET, Sachs R, Stern RE, Hirsh DM, Anderson Jr WJ. The pathology and treatment of metastatic disease of the femur. Clin Orthop Relat Res 1982; (169) 70-82
  • 48 Sim FH. Metastatic bone disease of the pelvis and femur. Instr Course Lect 1992; 41: 317-327
  • 49 Gainor BJ, Buchert P. Fracture healing in metastatic bone disease. Clin Orthop Relat Res 1983; (178) 297-302
  • 50 Mirels H. Metastatic disease in long bones. A proposed scoring system for diagnosing impending pathologic fractures. Clin Orthop Relat Res 1989; (249) 256-264
  • 51 Hultborn R, Gundersen S, Ryden S. , et al. Efficacy of pamidronate in breast cancer with bone metastases: a randomized, double-blind placebo-controlled multicenter study. Anticancer Res 1999; 19 (4C): 3383-3392
  • 52 O'Carrigan B, Wong MH, Willson ML, Stockler MR, Pavlakis N, Goodwin A. Bisphosphonates and other bone agents for breast cancer. Cochrane Database Syst Rev 2017; 10: CD003474
  • 53 Gnant M, Mlineritsch B, Schippinger W. , et al; ABCSG-12 Trial Investigators. Endocrine therapy plus zoledronic acid in premenopausal breast cancer. N Engl J Med 2009; 360 (07) 679-691
  • 54 Fizazi K, Lipton A, Mariette X. , et al. Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates. J Clin Oncol 2009; 27 (10) 1564-1571
  • 55 Stopeck AT, Lipton A, Body JJ. , et al. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. J Clin Oncol 2010; 28 (35) 5132-5139
  • 56 Sun S, Lang EV. Bone metastases from renal cell carcinoma: preoperative embolization. J Vasc Interv Radiol 1998; 9 (02) 263-269
  • 57 Chatziioannou AN, Johnson ME, Pneumaticos SG, Lawrence DD, Carrasco CH. Preoperative embolization of bone metastases from renal cell carcinoma. Eur Radiol 2000; 10 (04) 593-596
  • 58 Coleman RE. Skeletal complications of malignancy. Cancer 1997; 80 (8, Suppl): 1588-1594
  • 59 Menendez L. OKU Musculoskeletal Tumors (Orthopaedic Knowledge Update). 1st ed. Rosemont, IL: American Academy of Orthopaedic Surgeons; 2001
  • 60 Sarahrudi K, Greitbauer M, Platzer P, Hausmann JT, Heinz T, Vécsei V. Surgical treatment of metastatic fractures of the femur: a retrospective analysis of 142 patients. J Trauma 2009; 66 (04) 1158-1163
  • 61 Peterson JR, Decilveo AP, O'Connor IT, Golub I, Wittig JC. What are the functional results and complications with long stem hemiarthroplasty in patients with metastases to the proximal femur?. Clin Orthop Relat Res 2017; 475 (03) 745-756
  • 62 Steensma M, Boland PJ, Morris CD, Athanasian E, Healey JH. Endoprosthetic treatment is more durable for pathologic proximal femur fractures. Clin Orthop Relat Res 2012; 470 (03) 920-926
  • 63 Janssen SJ, Kortlever JT, Ready JE. , et al. Complications after surgical management of proximal femoral metastasis: a retrospective study of 417 patients. J Am Acad Orthop Surg 2016; 24 (07) 483-494
  • 64 Harrington KD, Sim FH, Enis JE, Johnston JO, Diok HM, Gristina AG. Methylmethacrylate as an adjunct in internal fixation of pathological fractures. Experience with three hundred and seventy-five cases. J Bone Joint Surg Am 1976; 58 (08) 1047-1055