Endoscopy 2019; 51(04): S190
DOI: 10.1055/s-0039-1681732
ESGE Days 2019 ePoster podium presentations
Saturday, April 6, 2019 14:00 – 14:30: Colon ESD 3 ePoster Podium 1
Georg Thieme Verlag KG Stuttgart · New York

RISK FACTOR OF LYMPH NODE METASTASIS IN ENDOSCOPICALLY RESECTED T1 COLORECTAL CANCER

GA Song
1   Gastoenterology, Pusan National University Hospital, Busan, Korea, Republic of
,
DH Baek
1   Gastoenterology, Pusan National University Hospital, Busan, Korea, Republic of
,
EY Park
1   Gastoenterology, Pusan National University Hospital, Busan, Korea, Republic of
,
JW Park
1   Gastoenterology, Pusan National University Hospital, Busan, Korea, Republic of
,
SH Lee
1   Gastoenterology, Pusan National University Hospital, Busan, Korea, Republic of
› Author Affiliations
Further Information

Publication History

Publication Date:
18 March 2019 (online)

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Aims:

Early colorectal cancer is defined as a carcinoma confined to the submucosa, regardless of lymph node (LN) status. The risk of LN metastasis in early colon cancer is ranging from 6.3% to 17%, and submucosal invasion more than 1000um, lymphovascular invasion (LVI), poor differentiation and tumor budding are well-known risk factor. We aimed to clarify the risk factors for LN metastasisin early colorectal cancer.

Methods:

We retrospectively analyzed the clinicopathologic features of endoscopically resected 262 submucosal invasive colon cancers from 2007 to 2017. Of them, we analyzed 141 tumors which underwent subsequent colectomy with lymph node dissection because of unfavorable pathologic findings.

Results:

The overall LN metastasis rate was 18.4% (26/141). In the univariate analysis, LVI (p= 0.017) and tumor budding (p= 0.008) were associated with LN metastasis. In the multivariate analysis, LVI and tumor budding were significantly associated with LN metastasis (odds ratio [OR], 3.824; confidence interval [CI], 1.146 – 12.824; p= 0.029 and OR.., respectively) and moderately-differentiated adenocarcinoma was also associated with LN metastasis (OR, 2.808; CI, 2.808 (1.047 – 7.529); p= 0.040). Submucosal depth was not associated with LN metastasis both in univariate and multivariate analysis.

Conclusions:

In this study, LVI, tumor budding, and moderately-differentiated adenocarcinoma were associated with LN metastasis in endoscopically resected submucosal invasive colorectal cancer which underwent subsequent radical colectomy with LN dissection. Submucosal invasion depth was not associated with LN metastasis.