Neuroendocrine tumors of the head and neck

Introduction:

NET are benign or malign tumors, from cells of the endocrine (hormonal) and nervous systems. 0,5 – 2% of the neoplasms are neuroendocrine tumors, which are mostly located in the gastrointestinal oder bronchopulmonal tract. Die incidence is about 9000/100000. 1% oft he head and neck tumors are NET. This study evaluates NET with different locations, its therapy and outcome.

Methods:

14 patients with a neuroendocrine tumor oft he head and neck between 2010 and 2017 were evaluated. 8 patients underwent an operation and adjuvant radiochemotherapy (RCT). 5 patients had a prim. RCT with curative intention. 1 patient had a palliative chemotherapy because of the progress after the radiochemotherapy.

Results:

The locations of the tumors are the larynx (n = 7), parotid gland (n = 2) and the parasinuses (n = 5). A resection in sano (R0) could be reached in 6 of 8 cases. The average survival rate was 19 ± 6 months. 2 tumor recurrences occurred aou of 14 patients. 1 patient died after 7 months und 1 patient is without recurrence after 32 months. 2 patients received had no benefit of the combined radiochemotherapy and died after 6 and 13 months. Die overall survival depents on the stage and the R0 resection of the tumors. Die R0 resection is better in comparison to the prim. According to the overall survival time

Conclusion:

Patients with NET of the head and neck have to be treated in specialized cancer centers. Each patient should receive an individual therapy depending to localization and histopathtological findings.

Publication History

Publication Date:
23 April 2019 (online)