Am J Perinatol 2020; 37(07): 716-721
DOI: 10.1055/s-0039-1688817
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Role of Oropharyngeal Administration of Colostrum in Very Low Birth Weight Infants for Reducing Necrotizing Enterocolitis: A Randomized Controlled Trial

Deepak Sharma
1  Department of Neonatology, National Institute of Medical Science, Jaipur, Rajasthan, India
Amandeep Kaur
2  Department of Pediatrics, National Institute of Medical Science, Jaipur, Rajasthan, India
Nazanin Farahbakhsh
3  Department of Pediatric Pulmonology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Sunil Agarwal
4  Helping Hand Polyclinic, Jaipur, Rajasthan, India
› Author Affiliations
Funding None.
Further Information

Publication History

06 January 2019

30 March 2019

Publication Date:
14 May 2019 (online)


Objective This study aimed to study the role of oropharyngeal administration of colostrum (OAC) in very-low-birth-weight infants for reducing necrotizing enterocolitis (NEC).

Study Design In this randomized controlled trial, 117 infants were enrolled, 59 were randomized to OAC group and 58 to routine care group. Infants with birth weight ≤ 1,250 g and/or gestational age ≤ 30 weeks were enrolled. Infants in OAC group received maternal colostrum (0.2 mL), 0.1 mL on either side, after 24 hours of postnatal life and were given every 2 hour for the next 72 hours irrespective of the enteral feeding status of the neonate. The primary outcome of the study was the incidence of NEC (stage 2 or 3).

Results Baseline characteristics were comparable between the two groups. There was no significant reduction in the incidence of NEC in OAC group (0 [0%] vs. 3 [7.1%]; p = 0.11). There was significant reduction of 7 days of hospital stay in OAC group (34.2 ± 5.7 vs. 41.5 ± 6.7 days; p = 0.04).The incidence of early-onset sepsis, late-onset sepsis, blood culture positive sepsis, and ventilator-associated pneumonia were comparable between the two groups.

Conclusion OAC is safe and reduces the duration of hospital stay.

Authors' Contributions

D.S., A.K., and S.A. conceived and designed the experiments. N.F. and S.A. analyzed the data. D.S. and A.K. wrote the first draft of the article. N.F. and S.A. contributed to the writing of the article. D.S., A.K., N.F., and S.A. agree with article results and conclusions. N.F. and S.A. jointly developed the structure and arguments for the article. D.S., A.K., N.F., and S.A. made critical revisions and approved the final version. All authors reviewed and approved the final article.

Ethical Approval

This study was approved by the ethics committee of Institutional Research Board. Consent was taken by patients for enrollment and publication of study.