Synlett 2019; 30(18): 2015-2021
DOI: 10.1055/s-0039-1690498
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© Georg Thieme Verlag Stuttgart · New York

Emerging Catalyst Control in Cobalt-Catalyzed Oxidative Hydrofunctionalization Reactions

Rong Zhu
Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. of China   Email: rongzhu@pku.edu.cn
› Author Affiliations
This work was supported by the ‘Thousand Talents Plan’ Youth Program, and startup fund from College of Chemistry and Molecular Engineering, Peking University and BNLMS.
Further Information

Publication History

Received: 18 June 2019

Accepted after revision: 09 July 2019

Publication Date:
25 July 2019 (online)

Abstract

Oxidative functionalization has emerged as an important pathway in Co-catalyzed hydrogen atom transfer (HAT) hydrofunctionalization reactions. Notably, evidence was found for the participation of organometallic intermediates in such radical-polar crossover processes. These findings provide opportunities for catalyst control that was previously absent in HAT catalysis. In this article, we summarize the recent progress towards this direction involving carbon–heteroatom bond-forming intra- and intermolecular reactions, including work from our own group.

1 Introduction

2 Oxidative Trapping by Solvents and Intramolecular Nucleophiles

3 Intermolecular Oxidative Hydrofunctionalization

4 Conclusion and Outlook

 
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