Efficient Synthesis of 5-Trifluoromethylthio-1,2,3-Triazoles: One-Pot Multicomponent Reaction from Elemental Sulfur and TMSCF3

Lin-Lin Zhang; Meng-Tian Li; Liang-Liang Shen; Qin-Pei Wu

doi:10.1055/s-0039-1690716

Synthesis, Table of Contents

Synthesis 2020; 52(02): 304-310
DOI: 10.1055/s-0039-1690716

paper

Efficient Synthesis of 5-Trifluoromethylthio-1,2,3-Triazoles: One-Pot Multicomponent Reaction from Elemental Sulfur and TMSCF₃

Authors

Lin-Lin Zhang
Meng-Tian Li
Liang-Liang Shen
Qin-Pei Wu∗

Abstract

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Abstract

A sequential multistep reaction toward 5-trifluoromethylthio-1,2,3-triazoles has been established, starting from alkynes, organoazides, S₈, and (trifluoromethyl)trimethylsilane (TMSCF₃). This reaction features mild conditions, easy operation, and readily available substrates.

Key words

copper iodide - sulfur - triazole - (trifluoromethyl)trimethylsilane - multicomponent reaction

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References

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Supplementary Material

Supporting Information (PDF)