Recent Trends in RSV Immunoprophylaxis: Clinical Implications for the Infant

Santiago Acero-Bedoya; Phillip S. Wozniak; Pablo J. Sánchez; Octavio Ramilo; Asuncion Mejias

doi:10.1055/s-0039-1691803

American Journal of Perinatology, Table of Contents

Am J Perinatol 2019; 36(S 02): S63-S67
DOI: 10.1055/s-0039-1691803

Review Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Recent Trends in RSV Immunoprophylaxis: Clinical Implications for the Infant

Santiago Acero-Bedoya

¹Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio

,

Phillip S. Wozniak

²Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio

,

Pablo J. Sánchez

²Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio

³Division of Neonatology, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio

⁴Division of Infectious Diseases, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio

,

Octavio Ramilo

¹Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio

⁴Division of Infectious Diseases, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio

,

Asuncion Mejias

¹Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio

⁴Division of Infectious Diseases, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio

⁵Departamento de Farmacologia y Pediatria, Facultad de Medicina de Malaga, Universidad de Malaga (UMA), Spain

› Author Affiliations

Abstract

Respiratory syncytial virus (RSV) remains the leading cause for hospitalizations in infants worldwide, resulting in significant health and financial burden. Since 1998, the humanized monoclonal antibody palivizumab remains the only available option licensed for the prevention of severe RSV disease in high-risk children, namely premature infants and those with chronic lung disease and congenital heart disease. In 2014, the American Academy of Pediatrics modified the recommendations on the use of RSV prophylaxis in these high-risk children, and limited its use to premature infants born at < 28 weeks' gestational age (wGA). Following this last guidance update, studies have confirmed that premature infants of 29 to 34 wGA remain at high risk for severe RSV disease, especially those of younger chronologic age. New and more cost-effective strategies are being developed that would help alleviate both the health and financial burden associated with severe RSV disease.

Keywords

respiratory syncytial virus - palivizumab - premature infants - disease severity - hospitalizations

Full Text

References

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