Abstract
Objectives In this study, a collagen-rich biomembrane obtained from porcine intestinal submucosa
for application in guided bone regeneration was developed and characterized. Then,
its biological and mechanical properties were compared with that of commercial products
(GenDerm [Baumer], Lumina-Coat [Critéria], Surgitime PTFE [Bionnovation], and Surgidry Dental F [Technodry]).
Materials and Methods The biomembrane was extracted from porcine intestinal submucosa. Scanning electron
microscopy, spectroscopic dispersive energy, glycosaminoglycan quantification, and
confocal microscopy by intrinsic fluorescence were used to evaluate the collagen structural
patterns of the biomembrane. Mechanical tensile and deformation tests were also performed.
Statistical Analysis The results of the methods used for experimental membrane characterizations were
compared with that obtained by the commercial membranes and statistically analyzed
(significance of 5%).
Results The collagen-rich biomembrane developed also exhibited a more organized, less porous
collagen fibril network, with the presence of glycosaminoglycans. The experimental
biomembrane exhibited mechanical properties, tensile strength, and deformation behavior
with improved average stress/strain when compared with other commercial membranes
tested. Benefits also include a structured, flexible, and bioresorbable characteristics
scaffold.
Conclusions The experimental collagen-rich membrane developed presents physical–chemical, molecular,
and mechanical characteristics similar to or better than that of the commercial products
tested, possibly allowing it to actively participating in the process of bone neoformation.
Keywords
extracellular matrix - porcine intestinal submucosa - guided bone regeneration
