Gesundheitswesen 2019; 81(08/09): 754-755
DOI: 10.1055/s-0039-1694636
Kongresstag 3: 18.09.2019
Georg Thieme Verlag KG Stuttgart · New York

Are daycare workers at a higher risk of CMV and parvovirus B19 infection? A systematic review and meta-analysis

K Romero Starke
1   Technische Universität Dresden, Universitätsklinikum Dresden, Institut und Poliklinik für Arbeits- und Sozialmedizin, Dresden
,
M Kofahl
1   Technische Universität Dresden, Universitätsklinikum Dresden, Institut und Poliklinik für Arbeits- und Sozialmedizin, Dresden
,
J Stranzinger
2   Institution for Statutory Social Accident Insurance and Prevention in the Health Care and Welfare Services (BGW), Basic Principles of Prevention and Rehabilitation, Section Occupational Health, Hamburg
,
A Nienhaus
2   Institution for Statutory Social Accident Insurance and Prevention in the Health Care and Welfare Services (BGW), Basic Principles of Prevention and Rehabilitation, Section Occupational Health, Hamburg
,
A Seidler
1   Technische Universität Dresden, Universitätsklinikum Dresden, Institut und Poliklinik für Arbeits- und Sozialmedizin, Dresden
› Author Affiliations
Further Information

Publication History

Publication Date:
23 August 2019 (online)

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Einleitung:

The aim of this review was to summarize the evidence on the relationship between being a daycare worker (DCW) working with children and the possible increased risk of cytomegalovirus (CMV) and parvovirus B19 infection.

Methode:

We searched the Medline and Embase databases using search strings defined according to PICO in order to find studies published since 2000. Two independent reviewers evaluated the search hits using predefined inclusion and exclusion criteria. A manual search was also performed. The resulting studies were extracted and assessed in eight domains of bias. The pooled CMV and parvovirus B19 risks for DCWs compared to an unexposed population were calculated.

Ergebnisse:

After evaluating the 7781 search hits and a manual search, six and four methodologically-adequate studies were identified for CMV and parvovirus B19, respectively. There was an indication of an increased CMV seroprevalence for DCWs compared to the unexposed population (prevalence ratio, PR = 1.54, 95% CI 1.33 – 1.77). For parvovirus B19, DCWs had an increased risk of parvovirus B19 infection for compared to the unexposed population (RR = 1.12, 95% CI 0.98 – 1.27) using prevalence estimators. They also had a higher parvovirus B19 seroconversion rate (RR = 2.63, 95% 1.27 – 5.45) in the low risk of bias study.

Diskussion:

Our findings suggest a higher CMV and parvovirus B19 risk for DCWs compared to an unexposed population. Notwithstanding the need for longitudinal and intervention studies, preventative efforts are needed. Considering the underestimation of the occupational seroconversion risk by prevalence-based estimators, both CMV and parvovirus B19 infections among DCWs may mostly be occupationally acquired.