J Pediatr Neurol
DOI: 10.1055/s-0039-1697040
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Periventricular Venous Infarction in an Extremely Premature Infant as the Cause of Schizencephaly

Norman Ilves
1  Radiology Clinic, Tartu University Hospital, Tartu, Estonia
2  Department of Radiology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia
,
Pilvi Ilves
1  Radiology Clinic, Tartu University Hospital, Tartu, Estonia
2  Department of Radiology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia
,
Katrin Õunap
3  Department of Clinical Genetics, United Laboratories, Tartu University Hospital, Tartu, Estonia
4  Department of Clinical Genetics, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia
,
Rael Laugesaar
5  Children's Clinic, Tartu University Hospital, Tartu, Estonia
6  Department of Pediatrics, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia
,
Dagmar Loorits
1  Radiology Clinic, Tartu University Hospital, Tartu, Estonia
,
Mare Lintrop
1  Radiology Clinic, Tartu University Hospital, Tartu, Estonia
2  Department of Radiology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia
,
Mairi Männamaa
5  Children's Clinic, Tartu University Hospital, Tartu, Estonia
6  Department of Pediatrics, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia
,
Tuuli Metsvaht
7  Anesthesiology and Intensive Care Clinic, Tartu University Hospital, Tartu, Estonia
› Author Affiliations
Sources of Funding This study was financed by the Estonian Research Council (PUT 148) and by the Estonian Science Foundation. No funding sources were used for the study design, for the collection, analysis, and interpretation of the data, for the writing of the report, or for the decision to submit the manuscript for publication
Further Information

Publication History

20 May 2019

05 July 2019

Publication Date:
20 September 2019 (online)

Abstract

Schizencephaly is a disorder of neuronal migration which has been hypothesized to arise from vascular ischemic lesion during the early phase of neuroembryogenesis. We describe a case of a premature boy born at 23 weeks of gestation with neonatal stroke. On the first day of life cranial ultrasonography detected a grade II intraventricular hemorrhage and on day 12 periventricular venous infarction. At the postconceptional age of 40 weeks, magnetic resonance imaging revealed a gray matter–lined cleft, suggesting schizencephaly. We have evidence of the pathogenesis of schizencephaly following vascular ischemic stroke early in neurodevelopment before neuronal migration is completed.

Disclosures

Informed consent for publishing the case report was obtained from the patient's mother. All authors have approved the final version of the manuscript