Abstract
Objective There is insufficient study of the association of blood groups with neonatal diseases.
The aim of this study was to evaluate the blood groups associated with sepsis and
blood groups in preterm infants.
Study Design This retrospective study was conducted between January 1, 2010 and November 31, 2018
in the neonatal intensive care unit (NICU). This study was done in single-center tertiary
NICU. Infants born at gestational age (GA) <32 weeks with birth weight (BW) <1,500 g
were included in the study.
Results A total of 2,548 infants were included. The culture-proven sepsis ratio (30.2%) was
the lowest in the O blood group and the highest in the AB blood group (37.5%) (p = 0.045). Meningitis ratio (6.5%) was significantly higher, and hospital stay (64.1 ± 33.9
days) was significantly longer in B blood group (respectively, p = 0.005, p < 0.001). In the AB blood group, GA (27.68 ± 1.12 weeks) was the lowest and early
onset sepsis (EOS) (40.1%) and mortality (28.9%) ratio were found to be statistically
higher (p < 0.001 for all groups). The AB group was significantly related to higher frequency
of EOS (odds ratio [OR] = 2.93, 95% confidence interval [CI] = 1.68–5.12, p = 0.000), in addition to mortality (OR = 1.1, 95% CI = 0.55–2.19, p = 0.001). The O group was found to be associated with lower risk of late onset sepsis
(LOS) (OR = 1.67, 95% CI = 1.06–3.058, p = 0.003) according to the model with corrected risk factor including GA, BW, and
time of hospitalization.
Conclusion Our study was the first study showing a relationship between certain blood groups
and EOS/LOS in premature infants as well as meningitis.
Keywords
blood groups - early onset sepsis - late onset sepsis - prematurity - neonatal sepsis
- very low birth weight
