Severe Hyponatraemia Associated with the Use of Arginine–Vasopressin in Two Neonates with Complex Congenital Heart Disease

Nicolas Leister; Daniel Rohe; Christine Schumacher; Uwe Trieschmann; Christoph Menzel; Tobias Hannes

doi:10.1055/s-0039-1700963

Journal of Pediatric Intensive Care, Table of Contents

J Pediatr Intensive Care 2020; 09(03): 213-215
DOI: 10.1055/s-0039-1700963

Case Report

Georg Thieme Verlag KG Stuttgart · New York

Severe Hyponatraemia Associated with the Use of Arginine–Vasopressin in Two Neonates with Complex Congenital Heart Disease

Authors

Nicolas Leister

¹Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Cologne, Cologne, Germany
Daniel Rohe

¹Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Cologne, Cologne, Germany
Christine Schumacher

¹Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Cologne, Cologne, Germany
Uwe Trieschmann

¹Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Cologne, Cologne, Germany
Christoph Menzel

¹Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Cologne, Cologne, Germany
Tobias Hannes

²Department of Paediatric Cardiology, University of Cologne, Cologne, Germany

³Department of Paediatric Critical Care Medicine and Neonatology, University Children's Hospital, Cologne, Germany

Abstract

We report two cases of neonates with complex congenital heart disease and volume, catecholamine, and corticosteroid refractory shock treated with arginine–vasopressin. Arginine–vasopressin was able to reverse critical hypotension, but both patients developed severe hyponatremia, which recovered after discontinuation of arginine–vasopressin. Close control and prompt substitution of serum sodium is required in neonates with advanced heart failure on high-dose vasopressin therapy.

Keywords

arginine–vasopressin - refractory shock - hypotension - hyponatremia - congenital heart disease

Full Text

References

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