Normal Hearing Function in Children Prenatally Exposed to Zika Virus

Maria Helena Magalhães Barbosa; Cristiane Fregonesi Dutra Garcia; Maria Clara de Magalhães Barbosa; Jaqueline Rodrigues Robaina; Arnaldo Prata-Barbosa; Marco Antonio de Melo Tavares de Lima; Antonio José Ledo Alves da Cunha

doi:10.1055/s-0039-3399539

International Archives of Otorhinolaryngology, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2020; 24(03): e299-e307
DOI: 10.1055/s-0039-3399539

Original Research

Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Normal Hearing Function in Children Prenatally Exposed to Zika Virus

Authors

Maria Helena Magalhães Barbosa

¹Department of Otorhinolaryngology, Universidade Federal do Rio de Janeiro, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, RJ, Brazil

²Department of Pediatrics, Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil
Cristiane Fregonesi Dutra Garcia

³Department of Phonoaudiology, Universidade Federal do Rio de Janeiro Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, RJ, Brazil
Maria Clara de Magalhães Barbosa

²Department of Pediatrics, Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil
Jaqueline Rodrigues Robaina

⁴Department of Epidemiology, Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil
Arnaldo Prata-Barbosa

²Department of Pediatrics, Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil

⁵Department of Pediatrics, Universidade Federal do Rio de Janeiro Maternidade Escola, Rio de Janeiro, RJ, Brazil
Marco Antonio de Melo Tavares de Lima

¹Department of Otorhinolaryngology, Universidade Federal do Rio de Janeiro, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, RJ, Brazil
Antonio José Ledo Alves da Cunha

⁵Department of Pediatrics, Universidade Federal do Rio de Janeiro Maternidade Escola, Rio de Janeiro, RJ, Brazil

⁶Department of Pediatrics, Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagão Gesteira, Rio de Janeiro, RJ, Brazil

Abstract

Introduction The association between prenatal Zika virus infection and hearing alterations in offspring has been the object of some studies, although few have assessed children without microcephaly. However, a current trend to include prenatal Zika virus exposure in the group of risk indicators for hearing loss is noted.

Objective To present a series of 27 children prenatally exposed to the Zika virus submitted to multiple hearing assessments over time.

Methods A cohort of children born to symptomatic mothers with laboratorial Zika virus infection confirmation during pregnancy was submitted to an otoacoustic emission test, auditory brainstem response test (automated, neurodiagnostic and frequency-specific), audiometry, and imitanciometry over a period of 36 months since birth. The hearing assessment was performed independently of the presence of microcephaly or other apparent signs of congenital Zika syndrome.

Results The hearing tests presented predominantly normal results. Some children had signs of middle ear pathology. The only microcephalic child had normal electrophysiological tests, as well as preserved audiometric thresholds, but presented altered motor responses to sound.

Conclusion Prenatal exposure to Zika virus does not always determine hearing impairment. This risk seems to be more associated to the severity of the central nervous system damage. Hearing screening and follow-ups of the affected children are important, as well as further research in this area.

Keywords

zika virus - hearing - prenatal injuries

Volltext

Referenzen

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