Abstract
Alcohol-related liver disease (ALD) is currently the leading indication for liver
transplantation in the United States. Among patients with ALD, those with acute alcoholic
hepatitis who do not respond to medical treatment have a 6-month mortality of 70%
without transplantation. Despite the high mortality, the majority of patients will
not be eligible for transplant, given that most centers follow the 6-month abstinence
rule. A handful of centers in Europe and the United States perform early liver transplantation
(< 6 months abstinence) in these patients, as it provides a substantial survival benefit.
Short-term outcomes for these recipients are favorable, and relapse rates parallel
those seen in alcoholic cirrhosis transplant recipients who have completed the 6-month
wait period. Moving forward, studies examining long-term outcomes and candidate selection
are necessary for this growing subset of liver transplant candidates.
Keywords
liver transplant - alcoholic hepatitis - liver disease
