The Roles of the Amygdala Kisspeptin System

Edouard G. A. Mills; Kevin T. O'Byrne; Alexander N. Comninos

doi:10.1055/s-0039-3400462

Seminars in Reproductive Medicine, Table of Contents

Semin Reprod Med 2019; 37(02): 064-070
DOI: 10.1055/s-0039-3400462

Review Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Roles of the Amygdala Kisspeptin System

Authors

Edouard G. A. Mills

¹Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
Kevin T. O'Byrne

²Department of Anatomy, Department of Women and Children's Health, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom
Alexander N. Comninos

¹Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom

³Department of Endocrinology, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, United Kingdom

Abstract

The hypothalamic hormone kisspeptin (encoded by the KISS1/kiss1 gene) is the master regulator of the reproductive axis with its role in controlling gonadotrophin hormone secretion now well characterized. However, identification of kisspeptin and its cognate receptor expression within the amygdala, a key limbic brain region whose functions contribute to a broad range of physiological and behavioral processes, has heightened interest concerning kisspeptins' role in the broader aspects of reproductive physiology. In this review, we detail the important developments and key studies examining the emerging functions of this kisspeptin population. These studies provide novel advances in our understanding of the mechanisms controlling reproductive neuroendocrinology by defining the crucial role of the amygdala kisspeptin system in modulating pubertal timing, reproductive hormone secretion, and pulsatility, as well as its influence in governing-related behaviors. To this end, the role of the amygdala kisspeptin system in integrating reproductive hormone secretion with behavior sheds new light onto the potential use of kisspeptin-based therapeutics for reproductive and related psychosexual disorders.

Keywords

kisspeptin - amygdala - pubertal timing - pulsatility - reproductive behavior

Full Text

References

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