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Open Access
CC BY 4.0 · VCOT Open 2019; 02(02): e64-e69
DOI: 10.1055/s-0039-3400513
Case Report
Georg Thieme Verlag KG Stuttgart · New York

A Case of Giant Cell Tumour of Bone in a Dog

Margaux Blondel 
1   Division of Small Animal Surgery, Department of Clinical Sciences, Ecole Nationale Vétérinaire de Toulouse, University of Toulouse, Toulouse, France
,
Lucile Gros
2   Division of Diagnostic Imaging, Department of Clinical Sciences, Ecole Nationale Vétérinaire de Toulouse, University of Toulouse, Toulouse, France
,
Marie-Odile Semin
3   Division of Pathology, Department of Biological and Fundamental Sciences, University of Toulouse, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France
,
Maxence Delverdier 
3   Division of Pathology, Department of Biological and Fundamental Sciences, University of Toulouse, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France
,
Sophie Palierne 
1   Division of Small Animal Surgery, Department of Clinical Sciences, Ecole Nationale Vétérinaire de Toulouse, University of Toulouse, Toulouse, France
,
André Autefage 
1   Division of Small Animal Surgery, Department of Clinical Sciences, Ecole Nationale Vétérinaire de Toulouse, University of Toulouse, Toulouse, France
› Author Affiliations
Funding None.
Further Information

Publication History

15 July 2019

15 October 2019

Publication Date:
31 December 2019 (online)

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Abstract

Case Description A 9-year-old neutered female mixed-breed dog was presented for the assessment of right pelvic limb lameness of 1-week duration. The lameness had progressed to non-weight bearing the day before presentation.

Diagnostic Findings Radiographic examination of the right stifle joint revealed a large purely lytic lesion affecting the proximal metaphysis and epiphysis of the right tibia associated with a pathological fracture of the tibial plateau. These findings, combined with histological evaluation of a bone biopsy performed under ultrasound-guidance, were suggestive of a giant cell tumour of bone.

Treatment and Outcome A limb-sparing procedure was attempted as first-line treatment. Curettage of the tumour was followed by coblation, and the defect was filled with polymethyl methacrylate bone cement. Physical and radiographic follow-up examinations 1, 2 and 3 months after surgery revealed improved functional outcome and minor progression of osteolysis. However, local recurrence was apparent 5 months after initial surgery and the limb was therefore amputated.

Clinical Relevance Giant cell tumour of bone is rare in dogs. In humans, the traditional surgical management is curettage. This treatment was attempted here for the first time in a dog and the short-term outcome was satisfactory. However, in this particular case, local control of the tumour was unsuccessful.

Keywords

giant cell - bone tumours - dogs - curettage - PMMA bone cement filling

Authors’ Contributions

All authors contributed to conception of study, study design, acquisition of data data analysis and interpretation. Margaux Blondel, Sophie Palierne and André Autefage drafted, revised and approved the submitted manuscript. Lucile Gros, Marie-Odile Semin and Maxence Delverdier approved the submitted manuscript.