New Insights on Pulmonary Paracoccidioidomycosis

Flá vio de Queiroz-Telles; Paula Massaroni Peçanha Pietrobom; Marcos Rosa Júnior; Rodrigo de Melo Baptista; Paulo Mendes Peçanha

doi:10.1055/s-0039-3400544

Seminars in Respiratory and Critical Care Medicine, Table of Contents

Semin Respir Crit Care Med 2020; 41(01): 053-068
DOI: 10.1055/s-0039-3400544

Review Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

New Insights on Pulmonary Paracoccidioidomycosis

Authors

Flá vio de Queiroz-Telles

¹Department of Public Health, Hospital de Clínicas, Federal University of Parana, Parana, Brazil
Paula Massaroni Peçanha Pietrobom

²Division of Infectious Diseases, Department of Medicine, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil
Marcos Rosa Júnior

³Section of Radiology, Department of Medicine, Hospital Universitário Cassiano Antônio de Moraes, Federal University of Espírito Santo, Espírito Santo, Brazil
Rodrigo de Melo Baptista

³Section of Radiology, Department of Medicine, Hospital Universitário Cassiano Antônio de Moraes, Federal University of Espírito Santo, Espírito Santo, Brazil
Paulo Mendes Peçanha

⁴Section of Infectious Diseases, Department of Medicine, Hospital Universitário Cassiano Antônio de Moraes, Federal University of Espírito Santo, Espírito Santo, Brazil

Abstract

Paracoccidioidomycosis (PCM) is one of the most relevant systemic endemic mycoses in Latin American countries, especially in South American countries, with endemic and hyperendemic areas. The real burden of PCM may be underestimated because of a lack of compulsory case notification. Recent phylogenetic data revealed that Paracoccidioides brasiliensis comprises several cryptic species including P. brasiliensis and P. lutzii. However, the genetic biodiversity of Paracoccidioides does not affect the clinical manifestations or therapeutic response to therapy. Lung involvement is a common finding, especially in patients experiencing the chronic form of the disease, and, because of its similarities with tuberculosis, clinicians must be alert to the possibility of PCM in patients with chronic respiratory manifestations and epidemiological risk factors for this fungal disease.

Keywords

paracoccidioidomycosis - Paracoccidioides - environment - lungs - axial computed tomography - pulmonary sequela - itraconazole - therapy

Full Text

References

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