Non-Aspergillus Hyaline Molds: Emerging Causes of Sino-Pulmonary Fungal Infections and Other Invasive Mycoses

Samantha E. Jacobs; Nancy L. Wengenack; Thomas J. Walsh

doi:10.1055/s-0039-3401989

Seminars in Respiratory and Critical Care Medicine, Inhaltsverzeichnis

Semin Respir Crit Care Med 2020; 41(01): 115-130
DOI: 10.1055/s-0039-3401989

Review Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Non-Aspergillus Hyaline Molds: Emerging Causes of Sino-Pulmonary Fungal Infections and Other Invasive Mycoses

Samantha E. Jacobs

¹Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York

,

Nancy L. Wengenack

²Division of Clinical Microbiology, Mayo Clinic Alix School of Medicine, Rochester, Minnesota

,

Thomas J. Walsh

³Departments of Medicine, Pediatrics, and Microbiology & Immunology, Transplantation-Oncology Infectious Diseases Program, Weill Cornell Medicine, New York, New York

› Institutsangaben

Abstract

Hyaline molds, widely distributed in nature, are an important and increasing cause of invasive fungal infections in humans, likely due to an expanding population of immunosuppressed hosts, increases in antifungal resistance, and improvements in laboratory diagnostics. Sinopulmonary disease and disseminated infection are common manifestations in neutropenic patients and transplant recipients, whereas, catheter-related and localized soft tissue infections predominate in immunocompetent hosts. These organisms are not reliably differentiated based on their morphology in tissue; rather, efforts should be made to establish a microbiologic diagnosis via culture or molecular-based methods to guide antifungal management and inform prognosis. Herein, we review the epidemiology, clinical manifestations, diagnosis, and management of these opportunistic pathogens known to cause hyalohyphomycoses: Scedosporium spp., Lomentospora prolificans, Fusarium spp., Scopulariopsis spp., Arthrographis kalrae, Trichoderma spp., Acremonium spp., Paecilomyces variotii, Purpureocillium lilacinum, and Penicillium species.

Keywords

Fusarium - Scedosporium - Scopulariopsis - Trichoderma - Acremonium - Arthrographis - Paecilomyces - Penicillium - hyalohyphomycoses

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