Ketogenic Diet as Medical Nutrition TherapyFunding None.
Medical nutrition therapy is a therapeutic approach to treat medical conditions and their associated symptoms via using a specifically tailored diet devised under the supervision of a doctor and a registered dietitian or nutrition professional. Ketogenic diet primarily consists of the high amount of fats, a moderate amount of proteins, and very low carbohydrates. It is known to stimulate the metabolic effects of starvation by forcing the body to use primarily fat as a fuel source. Ketogenic diet was developed in the 1920s. Nowadays, it is gaining considerable attention as a potential weight-loss strategy because of the low-carb diet. However, it is being considered for use in several diseases/disorders also because of the beneficial effects on the metabolic health and nervous system. This review revisits the therapeutic potential of ketogenic diets in many pathological conditions and its role as a medical nutrition therapy. It also talks about the ill effects that the keto diet can have in case of self-usage and monitoring.
Keywordsdiabetes - ketosis - medical nutrition therapy - ketogenic diet - metabolic health - obesity
Received: 29 June 2019
Accepted after revision: 05 November 2019
30 March 2020 (online)
Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India
- 1 The Charlie Foundation. Available at: https://charliefoundation.org/diet-plans
- 2 Hippocrates on the Sacred Disease. Available online: http://classics.mit.edu/Hippocrates/sacred.html. Accessed May 16, 2017
- 3 McDonald TJW, Cervenka MC. The expanding role of ketogenic diets in adult neurological disorders. Brain Sci 2018; 8 (08) 148
- 4 Ruskin DN, Masino SA. The nervous system and metabolic dysregulation: emerging evidence converges on ketogenic diet therapy. Front Neurosci 2012; 6: 33 DOI: 10.3389/fnins.2012.00033.
- 5 Pérez-Guisado J. [Ketogenic diets: additional benefits to the weight loss and unfounded secondary effects]. Arch Latinoam Nutr 2008; 58 (04) 323-329
- 6 Paoli A, Rubini A, Volek JS, Grimaldi KA. Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. Eur J Clin Nutr 2013; 67 (08) 789-796
- 7 Barañano KW, Hartman AL. The ketogenic diet: uses in epilepsy and other neurologic illnesses. Curr Treat Options Neurol 2008; 10 (06) 410-419
- 8 Kashiwaya Y, Takeshima T, Mori N, Nakashima K, Clarke K, Veech RL. D-β-hydroxybutyrate protects neurons in models of Alzheimer’s and Parkinson’s disease. Proc Natl Acad Sci U S A 2000; 97 (10) 5440-5444
- 9 Zhao Z, Lange DJ, Voustianiouk A. et al. A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis. BMC Neurosci 2006; 7: 29 DOI: 10.1186/1471-2202-7-29.
- 10 Di Lorenzo C, Coppola G, Di Lenola D. et al. Efficacy of modified Atkins ketogenic diet in chronic cluster headache: an open-label, single-arm, clinical trial. Front Neurol 2018; 9: 64 DOI: 10.3389/fneur.2018.00064.
- 11 Volek JS, Fernandez ML, Feinman RD, Phinney SD. Dietary carbohydrate restriction induces a unique metabolic state positively affecting atherogenic dyslipidemia, fatty acid partitioning, and metabolic syndrome. Prog Lipid Res 2008; 47 (05) 307-318
- 12 Mavropoulos JC, Yancy WS, Hepburn J, Westman EC. The effects of a low-carbohydrate, ketogenic diet on the polycystic ovary syndrome: a pilot study. Nutr Metab (Lond) 2005; 2: 35 DOI: 10.1186/1743-7075-2-35.
- 13 Di Lorenzo C, Coppola G, Sirianni G. et al. Migraine improvement during short lasting ketogenesis: a proof-of-concept study. Eur J Neurol 2015; 22 (01) 170-177
- 14 Vander Heiden MG, Locasale JW, Swanson KD. et al. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science 2010; 329 (5998): 1492-1499
- 15 Chung HY, Park YK. Rationale, feasibility and acceptability of ketogenic diet for cancer treatment. J Cancer Prev 2017; 22 (03) 127-134
- 16 Here Are the Worst Side Effects of the Keto Diet. https://www.healthline.com/health-news/worst-side-effects-of-the-keto-diet. Accessed December 20, 2019