Abstract
Clostridioides difficile remains a leading cause of healthcare-associated infection. Efforts at C. difficile prevention have been hampered by an increasingly complex understanding of transmission
patterns and a high degree of heterogeneity among existing studies. Effective prevention
of C. difficile infection requires multimodal interventions, including contact precautions, hand
hygiene with soap and water, effective environmental cleaning, use of sporicidal cleaning
agents, and antimicrobial stewardship. Roles for probiotics, avoidance of proton pump
inhibitors, and isolation of asymptomatic carriers remain poorly defined.
Keywords
Clostridioides difficile
- infection control - infection prevention
