NECROBIOTIC XANTHOGRANULOMA PRESENTING AS A CLINICAL VARIANT WITHOUT PARAPROTEINEMIA

Michelle Mathias; Harish S Permi; Padma Shetty; Jayaprakash Shetty K.; B. S. Girish

doi:10.1055/s-0040-1703527

Journal of Health and Allied Sciences NU, Table of Contents

CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2011; 01(01/03): 72-74
DOI: 10.1055/s-0040-1703527

Case Report

NECROBIOTIC XANTHOGRANULOMA PRESENTING AS A CLINICAL VARIANT WITHOUT PARAPROTEINEMIA

Authors

Michelle Mathias

Associate Professor, Department of Pathology, K.S. Hegde Medical Academy, Nitte University, Derlakatte, Mangalore ,INDIA
Harish S Permi

Assistant Professor, Department of Pathology, K.S. Hegde Medical Academy, Nitte University, Derlakatte, Mangalore ,INDIA
Padma Shetty

Professor, Department of Pathology, K.S. Hegde Medical Academy, Nitte University, Derlakatte, Mangalore ,INDIA
Jayaprakash Shetty K.

Professor and HOD, Department of Pathology, K.S. Hegde Medical Academy, Nitte University, Derlakatte, Mangalore ,INDIA
B. S. Girish

Associate Professor, Department of Dermatology, K.S. Hegde Medical Academy, Nitte University, Derlakatte, Mangalore ,INDIA

Abstract

PDF Download

Abstract

Necrobiotic xanthogranuloma is a rare granulomatous disease involving skin and subcutaneous tissues. A 61 year old woman presented with a 5 year history of enlarging plaques around both eyelids.it was associated with diminished vision in both eyes. The lesions are often bilateral,symmetrical and ophthalmologic complications are observed. A histopathological examination showed features of necrobiotic xanthogranuloma. Necrobiotic xanthogranuloma is usually associated with paraproteinemia which was not seen in our case.The pathogenesis remains unclear. Although there is no first line of treatment, reports have shown variable benefits with chemotherapeutic agent and steroids.

Keywords

necrobiotic xanthogranuloma - necrobiosis

PDF (64 kb)

References

References
1 Wee SA, Shupack Jerome G. Necrobiotic xanthogranuloma. Dermatology online journal 2005(4):24
2 Finan MC,WinklemanRK. Necrobiotic xanthogranuloma with paraproteinemia: a review of 22 cases.Medicine 1986;65:376
3 Mehregan DA,Winkleman RK. Necrobiotic xanthogranuloma. Arch Dermatol 1992;128:94
4 Winkleman RK, et al. Giant cell granulomatous pulmonary and myocardial lesions in necrobiotic xanthogranuloma with paraproteinemia. Mayo Clin Proc 1991;66: 1222
5 Shah KC, et al. necrobiotic xanthogranuloma with cutaneous and cerebral manifestations.J. Neurosurg 2004;100:1111
6 Machado S, et al. necrobiotic xanthogranuloma-sucessfully treated with low dose chlorambucil.Eur J dermatol 2001;11:458
7 Macfarlane AW,Verbov JL.Necrobiotic xanthogranuloma with paraproteinemia.Br J Dermatol 1985;113:339
8 Char DH, et al. Radiation therapy for ocular necrobiotic xanthogranuloma. Arch Ophthalmol1987;105:174
9 Chave TA, et al. Recalcitrant necrobiotic xanthogranuloma responding to pulsed high –dose oral dexamethasone plus maintenance therapy with oral prednisolone. Br J Dermatol 2001;144:158
10 Georgiou S, et al. Inteferon alpha-2a mono therapy for necrobiotic xanthogranuloma.Acta Derm Venereol(Stockh) 1999;79:484
11 Finelli LG, Ratz JL. Plasmapheresis, a treatment modality for necrobiotic xanthogranuloma. J Am Acad Dermatol 1987;17:351
12 Dupre A, Viraben R.Necrobiotic xanthogranuloma: a case without paraproteinemia but with transepithelial elimination. J Cutan Pathol 1988;15(2):116-9