Abstract
Langerhans cell histiocytosis most commonly occurring in children, demonstrates a
broad spectrum of clinical and radiologic features that may mimic those of infection
as well as benign and malignant tumors. Osseous involvement is the most common manifestation.
Recognition of the skeletal alterations is important so that the disease is considered
as differential diagnosis. This disease is of unknown aetiology, non-specific clinical
and imaging findings with diagnosis possible only on histopathological examination,
will always pose a diagnostic challenge to the orthopaedic surgeon. Here by we are
reporting two cases of eosinophilic granuloma that has presented with lytic lesion
in the tibia and scapula. The clinico-radiological suspicion was either infection
or tumour of the affected bones. Hence, core biopsy was done confirmed as eosinophilic
granuloma on histopathology and immunohistochemistry.
Keywords
eosinophilic granuloma - tumour - osteomyelitis - CD 1a
