Endoscopy 2020; 52(S 01): S70
DOI: 10.1055/s-0040-1704214
ESGE Days 2020 oral presentations
Friday, April 24, 2020 08:30-10:30 Squeeky clean Wicklow Meeting Room 1
© Georg Thieme Verlag KG Stuttgart · New York

EFFECTIVENESS AND TOLERABILITY OF NER1006 COMPARED TO HIGHER-VOLUME PEG PREPARATIONS FOR COLONOSCOPY: A PROSPECTIVE, MULTICENTER OBSERVATIONAL STUDY

M Maida
1   Gastroenterology and Endoscopy Unit, S. Elia-Raimondi Hospital, Caltanissetta, Italy
,
G Morreale
1   Gastroenterology and Endoscopy Unit, S. Elia-Raimondi Hospital, Caltanissetta, Italy
,
E Sinagra
2   Gastroenterology and Endoscopy Unit, Fondazione Istituto San Raffaele Giglio, Cefalù, Italy
,
S Sferrazza
3   Gastroenterology and Endoscopy Unit, Santa Chiara Hospital, Trento, Italy
,
G Scalisi
4   Gastroenterology Unit, ARNAS Garibaldi, Catania, Italy
,
D Schillaci
5   Basarocco Hospital, Niscemi, Italy
,
M Ventimiglia
6   Villa Sofia-Cervello Hospital, Department of Internal Medicine, Palermo, Italy
,
FS Macaluso
6   Villa Sofia-Cervello Hospital, Department of Internal Medicine, Palermo, Italy
,
G Vettori
3   Gastroenterology and Endoscopy Unit, Santa Chiara Hospital, Trento, Italy
,
G Conoscenti
2   Gastroenterology and Endoscopy Unit, Fondazione Istituto San Raffaele Giglio, Cefalù, Italy
,
C Di Bartolo
4   Gastroenterology Unit, ARNAS Garibaldi, Catania, Italy
,
D Catarella
4   Gastroenterology Unit, ARNAS Garibaldi, Catania, Italy
,
S Garufi
1   Gastroenterology and Endoscopy Unit, S. Elia-Raimondi Hospital, Caltanissetta, Italy
,
M Manganaro
1   Gastroenterology and Endoscopy Unit, S. Elia-Raimondi Hospital, Caltanissetta, Italy
,
CM Virgilio
4   Gastroenterology Unit, ARNAS Garibaldi, Catania, Italy
,
S Camilleri
1   Gastroenterology and Endoscopy Unit, S. Elia-Raimondi Hospital, Caltanissetta, Italy
› Author Affiliations
Further Information

Publication History

Publication Date:
23 April 2020 (online)

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Aims The effectiveness of bowel cleansing is essential for a quality colonoscopy since it affects diagnostic accuracy. The study aims to assess the efficacy and tolerability of the 1L PEG preparation with NER1006 (Plenvu Norgine, Harefield, UK), compared to 4L and 2L PEG solutions in a real-life setting.

Methods All in- and out-patients scheduled for a screening, surveillance or diagnostic colonoscopy, after an afternoon-only or afternoon-morning 1, 2 or 4L PEG-based preparation were consecutively enrolled from September 2018 to February 2019 in 5 Italian centres. Bowel cleansing was assessed through the Boston Bowel Preparation Scale (BBPS). Cleansing success was defined by a total BBPS≥6 with a partial BBPS≥2 in each segment and high-quality cleansing of the right colon by a partial BBPS=3. Tolerability was evaluated through a semi-quantitative scale.

Results Overall, 1289 patients meeting inclusion criteria were enrolled in the study. Of these, 490 performed a 4L PEG (Selgesse), 566 a 2L PEG (Moviprep or Clensia) and 233 a 1L PEG preparation (Plenvu).

A cleansing success was achieved in 72.4%, 74.1% and 90.1% (p< 0.001), while a high-quality cleansing of the right colon in 15.9%, 12.0% and 41.4% (p< 0.001) for 4L, 2L and 1L-PEG preparation groups, respectively. No serious adverse events were reported.

Multiple regression models confirmed that preparation with the 1L-PEG was an independent predictor of overall cleansing success over the 2L-PEG (OR=1.79, 95% CI=1.04-3.08; P=0.035), an independent predictor of high-quality cleansing of the right colon both over the 4L-PEG (OR=1.58, 95% CI=1.02-2.44; P=0.041) and the 2L-PEG (OR=3.13, 95% CI=2.08-4.72; P< 0.001), and an independent predictor of tolerability both over the 4L-PEG (estimate 0.57, 95% CI=0.25;0.90; P=0.001) and the 2L-PEG (estimate 0.72, 95% CI=0.41;1.03; P< 0.001).

Conclusions This study shows that the 1L-PEG preparation with NER1006 presents greater effectiveness compared to higher-volume PEG preparation with the advantage of better tolerability.