Endoscopy 2020; 52(S 01): S164
DOI: 10.1055/s-0040-1704506
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© Georg Thieme Verlag KG Stuttgart · New York

A COMPARATIVE EVALUATION OF RENAL FUNCTION IN INPATIENTS TAKING 4L- AND 1- PEG-BASED BOWEL PREPARATION: A POST-HOC ANALYSIS OF A MULTICENTRE PROSPECTIVE STUDY

ML Marca
1   University of Bologna, Department of Medical and Surgical Sciences, Bologna, Italy
,
S Piccirelli
2   Fondazione Poliambulanza, Digestive Endoscopy Unit, Brescia, Italy
,
E Rondonotti
3   Valduce Hospital, Gastroenterology Unit, Como, Italy
,
A Mussetto
4   Santa Maria delle Croci Hospital, Gastroenterology Unit, Ravenna, Italy
,
L Frazzoni
1   University of Bologna, Department of Medical and Surgical Sciences, Bologna, Italy
,
O Triossi
4   Santa Maria delle Croci Hospital, Gastroenterology Unit, Ravenna, Italy
,
F Bazzoli
1   University of Bologna, Department of Medical and Surgical Sciences, Bologna, Italy
,
F Radaelli
3   Valduce Hospital, Gastroenterology Unit, Como, Italy
,
L Fuccio
1   University of Bologna, Department of Medical and Surgical Sciences, Bologna, Italy
,
C Hassan
5   Nuovo Regina Margherita Hospital, Digestive Endoscopy Unit, Roma, Italy
,
C Spada
2   Fondazione Poliambulanza, Digestive Endoscopy Unit, Brescia, Italy
› Author Affiliations
Further Information

Publication History

Publication Date:
23 April 2020 (online)

Also available at
 

Aims Recently, a new 1-Liter polyethylene glycol (PEG) plus ascorbate bowel purge has been approved for bowel preparation (Plenvu). Concerns about the safety profile of this very-low preparation have been risen due to electrolyte shifts (in particular high serum sodium level) reported in registration trials. However, real-life data on safety profile of Plenvu are lacking. Aim of the study was to compare renal function and serum electrolytes levels in inpatients scheduled for colonoscopy prepared either with 4L- or 1L-PEG based purge.

Methods Multicentre prospective, comparative study. Consecutive colonoscopies among hospitalized patients were included. Laboratory tests were performed before the beginning and after the end of preparation.

Results Data on 133 patients (72 4L-PEG and 61 1L-PEG) were collected in four hospitals. The two populations (4L- vs 1L- PEG) did not differ according to mean age (78 vs 73 years), gender, median Charlson comorbidity index and ≥75% of bowel-prep intake (97% vs 93%). The medium time among lab assessment and the beginning/end of preparation was comparable between groups. Patients receiving 1L-PEG group had greater amount of IV fluid intake (>1000ml/die) during the bowel prep.

No significant electrolytes shift was observed after bowel preparation in the two groups, as well as glomerular filtration rate (GFR) and the hydratation state assessed by the hematocrit.

Tab. 1

Laboratory tests, before and after bowel preparation intake. IQR, interquartile range. GFR, glomerular filtration rate.

Difference in post- vs. pre- bowel prep serum lab tests, <median (IQR)

PEG-4L

PEG-1L

P

Sodium, mmol/L

1 (-1.5, 2)

1 (-2, 3)

0.346

Potassium, mmol/L

-0.1 (-0.4, 0.2)

0.0 (-0.3, 0.3)

0.128

GFR (CKD-EPI), mL/min/1.73 m2

0.0 (-3.1, 4)

-0.5 (-6.0, 2.5)

0.171

Hematocrit, %

0.5 (-0.7, 2.1)

0.7 (-1.4, 2.7)

0.935

Conclusions In this first real-life study performed in inpatients, no significant changes in renal function and serum electrolytes levels after bowel preparation for colonoscopy with 1L-PEG solution were observed.