Endoscopy 2020; 52(S 01): S192
DOI: 10.1055/s-0040-1704597
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EFFICACY AND SAFETY OF SODIUM PICOSULFATE-MAGNESIUM CITRATE IN BOWEL PREPARATION FOR ELDERLY IN KOREAN POPULATION: A PILOT STUDY

SH Kim
1   Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
,
KW Lee
1   Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
,
S Kim
1   Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
,
SH Jang
1   Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
,
HJ Jeon
1   Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
,
SJ Choi
1   Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
,
JM Lee
1   Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
,
HS Choi
1   Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
,
ES Kim
1   Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
,
B Keum
1   Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
,
YT Jeen
1   Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
,
HS Lee
1   Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
,
HJ Chun
1   Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
,
CD Kim
1   Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
› Author Affiliations
Further Information

Publication History

Publication Date:
23 April 2020 (online)

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Aims Bowel preparation is one of the most important colonoscopy quality indicators. Sodium picosulfate-magnesium citrate (SP-MC) is getting more attention for its better tolerance and patient satisfaction compared to PEG-based solutions. However, its efficacy and safety in elderly patients has not been verified enough in Korean population. We compared the efficacy and safety of SP-MC compared to polyethyleneglycol (PEG) based bowel preparations in the elderly.

Methods A prospective, randomized, controlled trial was conducted at Korea University Anam Hospital. 70 outpatients and 68 inpatients who were over 65 years of age randomized to either PEG or SP-MC group. Bowel preparation quality was recorded in a blinded manner by the endoscopist using the Boston Bowel Preparation Scale (BBPS). Patient satisfaction was studied by questionnaire before colonoscopy. Side effects including hyponatremia and acute kidney injury were monitored by laboratory test following bowel preparation.

Results Baseline characteristics between the two groups were similar. BBPS score did not defer significantly between the two groups (PEG: SPMC, 6.97: 7.49, P = 0.131). Adenoma detection rates were also similar (PEG: SPMC, 51.5%: 52.9%, P = 0.805). Proportion of patients who answered more satisfactory than previous bowel preparation were higher in the SPMC group (24.3% vs 60.2%, P < 0.001). There was no reported acute kidney injury or electrolyte imbalance following preparation in both groups.

Conclusions Bowel preparation quality with the use of SP-MC was not inferior to PEG based preparation with even better patient satisfaction. Incidence of electrolyte imbalance or decline in renal function was not observed. SPMC is expected to be safely used in elderly without chronic renal diseases.