Am J Perinatol 2021; 38(S 01): e33-e38
DOI: 10.1055/s-0040-1705136
Original Article

Growth from Birth to 30 months for Infants Born with Congenital Gastrointestinal Anomalies and Disorders

Katie M. Strobel
1  Division of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Mattel Children's Hospital at UCLA, Los Angeles, California
,
Isabell Purdy
1  Division of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Mattel Children's Hospital at UCLA, Los Angeles, California
,
Tahmineh Romero
2  Division of General Internal Medicine and Health Services Research, Department of Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California
,
1  Division of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Mattel Children's Hospital at UCLA, Los Angeles, California
› Author Affiliations
Funding K.M.S. received funding from Children's Discovery and Research Institute at the University of California Los Angeles.

Abstract

Objective This study aimed to investigate growth among neonates with gastrointestinal disorders.

Study Design Inclusion criteria included neonates with gastroschisis, omphalocele, intestinal atresia, tracheoesophageal fistula, Hirschsprung's disease, malabsorption disorders, congenital diaphragmatic hernia, and imperforate anus born between 2010 and 2018. Anthropometrics were collected for the first 30 months, and a subgroup analysis was performed for gastroschisis infants.

Results In 61 subjects, 13% developed severe growth failure within the first month. One-, four-, and nine-month weight and length z-scores were less than birth weight in all infants (p < 0.05). In infants with gastroschisis, a similar pattern was observed for weight z-scores only (p < 0.05). From birth to 15 months, head circumference z-score increased over time in all infants (p = 0.001), while in gastroschisis infants, weight, length, and head circumference z-scores increased over time (p < 0.05).

Conclusion In a cohort of infants with gastrointestinal disorders, growth failure was followed by catch-up growth.

Authors' Contributions

K.M.S. and K.L.C. conceived and designed the study. K.M.S. acquired the data. K.M.S. and T.R. analyzed the data. K.M.S., I.P., T.R., and K.L.C. interpreted the data. K.M.S. drafted the manuscript. K.M.S., I.P., T.R., and K.L.C. critically reviewed and approved the manuscripts. All authors agree to be accountable for the work.




Publication History

Received: 13 December 2019

Accepted: 22 January 2020

Publication Date:
13 March 2020 (online)

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