DOI: 10.1055/s-0040-1705662
Association of Obstructive Parameters of Lung Functions Estimated by Spirometry with Risk Factors for Cardiovascular Disease among Women of Tertiary Care Hospital
Abstract
Background Declining lung functions is associated directly with cardiovascular diseases like heart failure or coronary artery disease, or the risk factors leading to cardiovascular mortality like arterial stiffness, pulse wave velocity, hypertension, etc. Exclusive studies in women are not frequently performed.
Aim The aim is to study the association between obstructive lung function estimated through spirometry and cardiovascular risk indicators like hypertension and arterial pulse wave velocity measured between carotid and femoral arteries (cf-PWV) in women.
Methods A total of 30 postmenopausal women on regular treatment for hypertension were recruited in the study. They were subjected to spirometry and computerized cf-PWV estimation. Women were grouped according to modified global initiative for chronic obstructive lung disease (GOLD) criteria into three groups with increasing severity of obstructive lung function.
Results Diastolic blood pressure (p = 0.04), pulse pressure (p < 0.0001), and cf-PWV (p = 0.009) were found to be significantly different between the three groups. Negative correlation existed between cf-PWV and %pred forced expiratory volume in 1 second (FEV1) in the group with most severe obstructive lung function (Pearson correlation coefficient r = 0.7610 was significant at p = 0.01). The strength of this negative association decreased as the severity deceased (r = 0.5603, significant at p = 0.03).
Conclusion Strong association between severity of obstructive lung function in postmenopausal women with pulse pressure was in lines with previous studies, but the diastolic blood pressure being associated is a novel finding. Also, the degree of obstructive lung function is positively associated with arterial stiffness which is an important indicator for impending cardiovascular mortality.
Publication History
Publication Date:
16 March 2020 (online)
© 2020. Women in Cardiology and Related Sciences. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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References
- 1 Johnston AK, Mannino DM, Hagan GW, Davis KJ, Kiri VA. Relationship between lung function impairment and incidence or recurrence of cardiovascular events in a middle-aged cohort. Thorax 2008; 63 (07) 599-605
- 2 Duprez DA, Hearst MO, Lutsey PL. et al. Associations among lung function, arterial elasticity, and circulating endothelial and inflammation markers: the multiethnic study of atherosclerosis. Hypertension 2013; 61 (02) 542-548
- 3 Jankowich MD, Taveira T, Wu W-C. Decreased lung function is associated with increased arterial stiffness as measured by peripheral pulse pressure: data from NHANES III. Am J Hypertens 2010; 23 (06) 614-619
- 4 Pan J, Xu L, Lam TH. et al. Relationship between pulmonary function and peripheral vascular function in older Chinese: Guangzhou biobank cohort study-CVD. BMC Pulm Med 2018; 18 (01) 74
- 5 Okamoto M, Shipley MJ, Wilkinson IB. et al. Does poorer pulmonary function accelerate arterial stiffening?: a cohort study with repeated measurements of carotid-femoral pulse wave velocity. Hypertension 2019; 74 (04) 929-935
- 6 Birhan MM, Abebe Y. Pulmonary function tests in hypertensive patients attending Zewditu Memorial Hospital, Addis Ababa, Ethiopia. Int J Hypertens 2018; (14) 1-7
- 7 Swati S, Shaikh M, Gupta Y, Nahar P, Zingade U, Kowale A. Pulmonary function tests in hypertension. Int J Hypertens 2014; 5 (07) 1-7
- 8 Silvestre OM, Nadruz Jr W, Querejeta Roca G. et al. declining lung function and cardiovascular risk: the ARIC study. J Am Coll Cardiol 2018; 72 (10) 1109-1122
- 9 Wang B, Zhou Y, Xiao L. et al. Association of lung function with cardiovascular risk: a cohort study. Respir Res 2018; 19 (01) 214
- 10 Li L, Hu B, Gong S, Yu Y, Dai H, Yan J. Pulmonary function and arterial stiffness in chronic heart failure. BioMed Res Int 2016; 2016: 5478394
- 11 Schnabel E, Nowak D, Brasche S, Wichmann HE, Heinrich J. Association between lung function, hypertension and blood pressure medication. Respir Med 2011; 105 (05) 727-733
- 12 Amaral AFS, Patel J, Gnatiuc L, Jones M, Burney PGJ. Association of pulse wave velocity with total lung capacity: a cross-sectional analysis of the BOLD London study. RespirMed (Baltimore) 2015; 109: 1569-1575
- 13 Medarov BI, Pavlov VA, Rossoff L. Dirunal variations in human pulmonary function. Int J Clin Exp Med 2008; 1: 267-273
- 14 Aggarwal AN, Agarwal R, Dhooria S. et al. Joint Indian Chest Society—National College of Chest Physicians (India) guidelines for spirometry. Lung India 2019; 36 (suppl): S1-S35
- 15 Swanney MP, Ruppel G, Enright PL. et al. Using the lower limit of normal for the FEV1/FVC ratio reduces the misclassification of airway obstruction. Thorax 2008; 63 (12) 1046-1051
- 16 Salpeter SR, Ormiston TM, Salpeter EE. Cardiovascular effects of β-agonists in patients with asthma and COPD: a meta-analysis. Chest 2004; 125: 2309-2321
- 17 Ohta K, Fukuchi Y, Grouse L. et al. A prospective clinical study of theophylline safety in 3810 elderly with asthma or COPD. Respir Med 2004; 98 (10) 1016-1024
- 18 Xie A, Skatrud JB, Puleo DS, Morgan BJ. Exposure to hypoxia produces long-lasting sympathetic activation in humans. J Appl Physiol (1985) 2001; 91 (04) 1555-1562