Vitamin B₁₂-Catalyzed Dicarbofunctionalization of Bromoalkenes Under Visible Light Irradiation

Dedicated to Professor Grzegorz Mlostoń on the occasion of his 70^th birthday.

Abstract

Vitamin B₁₂ plays a crucial role in enzymatic transformations. This natural compound proved also useful as a catalyst in numerous organic reactions. Commercial availability and lower cost than precious metal complexes, make cobalamin an attractive candidate for a broader use as a benign Co-catalyst. Herein, the vitamin B₁₂-catalyzed dicarbofuntionalization of bromoalkenes with electrophilic olefins is reported leading to substituted pyrrolidines and piperidines in decent yields after only 15 minutes under light irradiation.

Key words

cobalt - vitamin B12 - radical cyclization - Giese addition

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