Nickel-Catalyzed anti-Selective Alkyne Functionalization Reactions

Abstract

Nickel-catalyzed anti-selective alkyne functionalization reactions are reviewed with an emphasis on the mechanisms that lead to their observed stereoselectivity. Since the isomerization of alkenylnickel species plays a key role in a large number of these reactions, the potential mechanisms for these processes are also described in detail.

1 Introduction

2 anti-Selective Hydroarylation

3 anti-Selective Carboborylation

4 anti-Selective Dicarbofunctionalization

4.1 Carbocyanative Cyclization

4.2 Cyclization with Aryl Donors

4.3 Cyclization with CO₂

4.4 Intermolecular Dicarbofunctionalization

5 anti-Selective Carbosulfonylation

6 Alkenylnickel Isomerization

7 Conclusions

Key words

alkyne difunctionalization - Ni-catalyzed - cross-coupling - anti-selective - mechanistic studies - alkenylnickel

• References


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